淮北市妇幼保健院临产妇血清胱抑素C、视黄醇结合蛋白、总胆汁酸及前白蛋白正常参考范围研究

Study on normal reference range of cystatin C,retinol-binding protein,total bile acid and prealbumin in maternal serum in Huaibei Maternal and Child Health Hospital

目的探讨临产孕妇血清中胱抑素C(cystatin c,Cys-C)、视黄醇结合蛋白(retinol-binding protein,RBP)、总胆汁酸(total bile acid,TBA)及前白蛋白(prealbumin,PA)变化与妊娠晚期的相关性以及确定其生化指标正常参考值的范围。方法选取2015年5~7月淮北市妇幼保健院248例健康临产孕妇为研究组,同期100例健康育龄期非妊娠女性为对照组,分别检测两组患者血清中Cys-C、RBP、TBA及PA。结果研究组血清中TBA、Cys-C高于对照组,RBP、PA低于对照组,差异均有统计学意义(P<0.05)。确定本院临产妇生化指标正常参考值范围为Cys-C(0.75~1.35 mg/L)、RBP(21.6~50.2 mg/L)、TBA(2~16 umol/L),PA(200~310 mg/L)。结论临产妇的消化系统、内分泌系统及泌尿生殖系统发生一系列变化及胎儿生长发育所需的营养物质增多,导致母体内代谢发生变化,以致上述生化指标发生一系列生理性改变。确定临产妇生化指标的正常参考范围,有利于产科医生对临产妇各项生化指标做出正确判断,区别临产妇正常妊娠和病理妊娠,为产妇及胎儿的安全提供更好的保障。

Objective To investigate the pregnant women serum cystatin C （ Cys - C）, retinol binding protein（ RBP）, total bile acid（TBA） and prealbumin（PA） changes and correlation with late pregnancy, and determine the range of normal reference value of the biochemical indexes. Methods 248 healthy pregnant women in labor from May to July 2015 in Huaibei Maternal and Child Health Hospital were selected as the study group and 100 healthy non pregnant women of childbearing age were selected as the control group. The levels of Cys - C, RBP, TBA and PA in the serum of the two groups were detected and compared respectively. Results The serum levels of TBA and Cys - C in the study group were significantly higher than those in the control group （ P 〈 0. 05 ）. The serum RBP and PA in the study group were significantly lower than those in the control group（ P 〈 0. 05 ）. The normal reference values for the biochemical indicators of maternal women in this study ranged from Cys - C（0.75 - 1.35 mg/L）, RBP（21.6 -50.2 mg/L）, TBA（2 - 16 umol/L）, and PA （200 - 310 mg/L）. Conclusion A series of changes in the digestive system, endocrine system and urogenitalsystem of maternal women and the increase of nutrients required for fetal growth and development lead to changes in metabolism in the motherg body, resulting in a series of physiological changes in the above biochemical indicators. Determining the normal reference range of maternal biochemical indicators is conducive to the obstetrician making correct judgments on the maternal biochemical indicators, distinguishing maternal normal pregnancy and pathological pregnancy, and providing better protection for maternal and fetal safety.