摘要
目的:优化渗透泵微丸丸芯的处方、制备工艺,为渗透泵载药微丸研究提供优质丸芯。方法:在单因素的基础上,以休止角、硬度为评价指标,采用Box-Behnken法优选渗透丸芯的最佳制备工艺。结果:由单因素试验及Box-Behnken试验可知,以乳糖-微晶纤维素-PVP(5∶1∶0.1,w/w)为丸芯组成,以挤出转速30r·min^(-1),挤出温度24℃,滚圆转速1 800r·min^(-1)为最佳制备工艺,制得粒径为0.8mm,休止角为28.42°,硬度为17.52kg·cm-2的丸芯。结论:本实验筛选出渗透泵丸芯的处方组成及制备工艺,可为以渗透压为动力的渗透泵丸芯的制备研究提供参考。
OBJECTIVE To optimize the formula of osmotic pump pellets and preparation process for osmotic pump drugloaded pellets.METHODS On the basis of a single factor,with the angle of repose and hardness as evaluation indexes,the preparation process of osmotic pump pellets was optimized by Box-Behnken method.RESULTS Single factor test and Box-Behnken test showed that the pellet core with a particle size of 0.8 mm,a resting angle of 28.42 degree and a hardness of 17.52 kg·cm2 was prepared to produce pellets composed of lactose and microcrystalline cellulose-PVP(5∶1∶0.1,w/w),under the following optimum conditions:extrusion speed 30 r·min-1,the extrusion temperature 24 ℃,the speed of spheronization 1 800 r·min-1.CONCLUSION The formula and preparation process of osmotic pump pellets are screened out in this experiment,which can be used as a reference for the preparation of osmotic pump pellets with osmotic pressure as power for drug release.
作者
赵锋
闫森
赵梦瑶
刘佳慧
孙梦轩
杜青
ZHAO Feng;YAN Sen;ZHAO Meng-yao;LIU Jia-hui;SUN Meng-xuan;DU Qing(School of Pharmacy, Hehei Medical University, Hebei Shijiazhuang 050017,China)
出处
《中国医院药学杂志》
CAS
北大核心
2018年第13期1377-1383,共7页
Chinese Journal of Hospital Pharmacy
基金
河北省自然基金(H2017206158)
河北省卫生厅医学科学研究重点课题(20170742)
河北省卫生厅科研基金项目(20120217)
河北医科大学大学生创新性实验计划项目(USIP2016077)