生长分化因子15与消化系统肿瘤的研究进展

Research progress of growth differentiation factor 15 in digestive tumor

目的探讨生长分化因子15(GDF15)在消化系统肿瘤中的作用。方法检索国内外有关GDF15与消化系统肿瘤的基础与临床研究进展相关的文献并进行综述和分析。结果基础研究揭示GDF15在肿瘤组织和细胞中广泛表达,通过影响细胞信号转导导致细胞产生不同的生物学行为,在肿瘤演变过程中扮演了多重角色;临床研究发现,GDF15与消化系统肿瘤,尤其是与直结肠癌、肝癌和胰腺癌关系密切,有助于良性和恶性肿瘤的鉴别、早期诊断和预后评价,可能是肿瘤的潜在生物学标志物及治疗靶点。结论现有研究认为GDF15在消化系统肿瘤的发病中起到一定作用,也取得了一些进展,今后的研究应就GDF15在疾病不同阶段的变化和作用及其分子机制做进一步研究。

Objective To have more insight into roles of growth differentiation factor-15 （GDF15） in digestive tumor. Method The basic and clinical studies on the GDF15 in the digestive tumors published were searched in the databases for summarizing the latest advances on this issue. Results The GDF15, a novel member of transforming growth factor-β superfamily, played the diverse roles in the progress of the various diseases. The increasing number of evidence indicated that the GDF 15 was associated with the diagnosis and prognostication of the digestive tumors, eg： colorectal cancer, hepatocellular carcinoma, pancreatic adenocarcinoma, and might serve as a potential biomarker and therapeutic target for the multiple digestive tumors. Conclusions Current basic and clinical studies provide some evidences that GDF15 plays a role in digestive tumors. Further studies are needed to elucidate its roles and molecular mechanisms in different stages of diseases.