原发性结直肠印戒细胞癌的研究进展

Research advances of primary colorectal signet-ring cell carcinoma

目的总结原发性结直肠印戒细胞癌的研究进展。方法检索近年来国内外有关结直肠印戒细胞癌的相关文献,对其研究进展作一综述。结果结直肠印戒细胞癌是结直肠腺癌的一种病理学亚型,发病率极低,但恶性程度高、预后差。目前其分子机制仍不十分清楚,临床病理表现无明显特异性,治疗则以手术治疗为主。结论虽然我们对结直肠印戒细胞癌已经有了一定程度的了解,但由于较多相关文献的样本较小,或为单中心研究,因而研究结果存在局限,故未来仍需更多的研究来提高对结直肠印戒细胞癌的认知。

Objective To summarize the current research advances of colorectal signet-ring cell carcinoma （SRCC）. Methods In this paper, the related literatures of colorectal SRCC in recent years were collected and reviewed. Results Colorectal SRCC was a pathological subtype of colorectal adenocarcinoma, with extremely low incidence but high malignancy and poor prognosis. At present, its molecular mechanism was still not very clear and the clinicopathological manifestations were not specific. Surgical treatment was the major treatmen. Conclusions Although we already have a certain degree of understanding about colorectal SRCC, due to the limitations in the results of some related researches because of the small sample size or the single-center study, we still need more researches to improve the cognition of colorectal SRCC.