光相干断层扫描联合微视野检查在糖尿病黄斑水肿中的应用研究进展

Research progress of optical coherence tomography combined with microperimetry in diabetic macular edema

糖尿病黄斑水肿（DME）是非增生期糖尿病视网膜病变患者视力损害的主要原因。光相干断层扫描（OCT）可以检测DME患者视网膜各层厚度，发现视网膜层间的病理改变。微视野检查可以定性、定量地获得受检者视网膜特定位置的光敏感度，同时分析固视状态。通过OCT可以进一步观察DME视网膜的病理性解剖结构改变，并可根据相应微视野检查结果理解结构改变和功能下降的相应关系。目前针对于DME患者的治疗方式多样，主要疗效评估方式是通过OCT观察治疗前后视网膜病理改变是否改善、消失，联合微视野检查还可以获知接受治疗后患者视功能的恢复情况。联合应用OCT和微视野检查，在DME患者的诊断、治疗方面有着广泛的应用前景。

Diabetic macular edema is the major cause of vision impairment in patients with non-proliferative diabetic retinopathy. Thickness and pathological alterations in each retina layer of diabetic macular edema （DME） patients can be performed by optical coherence tomography （OCT） device. And retinal light sensitivity at specific retinal point and fixation state can be detected by microperimetry qualitatively and quantitatively. Moreover, OCT can discover pathological anatomical changes in the retina of DME patients, thus facilitating the interpretation of the structure-function relationship in DME with combination of microperimetry results. At present, there are various therapies for DME patients, and the primary method in evaluating therapeutic efficacy is to compare the pathological changes in the retina before and after treatment by OCT. Besides, microperimetry can provide information in visual function restoration. The combined application of OCT and microperimetry has broad prospects in the diagnosis and treatment of DME patients.