消渴病无毒植物药古方用药规律分析

Patterns of Non-toxic Botanical Drugs in Ancient Formulas for Diabetes

本研究运用Python编程语言和R统计分析软件,系统整理了清代及清代以前治疗消渴的有效方药,对无毒植物药组成的古方进行了用药规律总结,以期指导消渴病临床选方用药。本研究统计结果表明清代及以前无毒植物药治疗消渴病多集中于益气、养阴、清热药的使用,体现了消渴病气阴两虚、阴虚燥热的主要病机;消渴病复杂多变,常见肺胃燥热饮水无度、胃腑实热引饮常渴、血虚津亏四肢烦热、肺肾阴虚虚火上炎咳嗽、脾虚不能食、肾阳虚小便多、气虚水停遍身浮肿、气阴两伤等不同证候及其兼证,分析所得药对及所聚类的新方对上述证候及其兼症具有针对性,可为临床选方、配伍、化裁提供思路和依据。

The Python programming language and R statistical analysis software were used to systematically analyze the non-toxic botanical formulas for diabetes from the Qing dynasty and previous dynasties and summarize their prescription rules to guide clinical application for diabetes. The statistical results showed that non-toxic botanical formulas for diabetes focused on Qi-supplementing,Yin-tonifying and heat-clearing herbs,indicating the basic pathogenesis of diabetes： Qi-Yin deficiency and dryness-heat. Diabetes is a complex disease with a variety of complications,which correspond with different syndromes and pathogenesis from traditional Chinese medicine perspective. It had different syndromes and complications such as anorexia due to spleendeficiency,polyuria caused by kidney Yang deficiency,polydipsia resulted from lung-stomach dryness-heat,thirsty induced by excessive stomach heat,vexing heat in the limbs caused by blood and fluid deficiency,cough caused by lung-kidney Yin deficiency and hyperactivity of deficient fire,edema caused by Qi deficiency and impairment of both Qi and Yin. The prescription rules and new prescriptions obtained through cluster analysis were based on the syndrome differentiation,providing new ideas and evidence for properly selecting and modifying formulas to achievethe optimal therapeutic effects.