7.5%高渗盐水的不同给药方式对大鼠重型颅脑损伤后颅内压及血压的影响

Influence of different methods for the administration of 7.5% hypertonic saline on intracranial pressure and blood pressure in rats with severe traumatic craniocerebral injury

目的建立大鼠重型颅脑损伤模型,比较7.5%高渗盐水(HS)三种不同给药方式对重型颅脑损伤大鼠颅内压(ICP)及血压(MBP)的影响。方法将50只健康雄性SD大鼠随机分为A组、B组、C组、生理盐水组、空白对照组,每组10只。造模后A组采用快速输注方式、B组采用缓慢输注方式、C组采用先快速后缓慢输注的方式,比较给药前及给药后1-6h内ICP及MAP的变化。结果 (1)7.5%HS三种给药方式ICP均会下降(2)A、B、C三组在ICP最低值、药物起效时间、ICP降至最低用时方面均有统计学差异(P<0.001).(3)三组ICP降幅及用药前后MBP无统计学差异(P>0.05)(4)生理盐水组输注前后颅内压无明显变化。结论 (1)7.5%HS不同给药方式均会降低颅内高压(2)快速输注组起效时间更快,维持时间最长,降颅内压效果明显。

Objective To establish a rat model of severe traumatic craniocerebral injury, and to investigate the influence of three methods for the administration of 7.5% hypertonic saline （HS） on intracranial pressure （ICP） and mean blood pressure （MBP） in rats with severe traumatic craniocerebral injury. Methods A total of 50 healthy male Sprague-Dawley rats were randomly divided into group A, group B, group C, normal saline group, and blank control group, with 10 rats in each group. After modeling, group A was administered by rapid infusion, group B was administered by slow infusion, and group C was administered by rapid infusion followed by slow infusion, and the three groups were compared in terms of the changes in ICP and MBP at 1 - 6 hours after administration. Results Groups A, B, and C had a significant reduction in ICP after the administration of 7.5% HS, and there were no significant differences between groups A, B, and C in the lowest value of ICP, drug onset time, and time for ICP to decrease to the lowest level （P 〈0.001 ）. There were also no significant differences between these three groups in the reduction in ICP and MBP before and after administration （P 〉 0.05）. The normal saline group showed no significant change in ICP after administration. Conclusions All three methods for the administration ofT. 5% HS can reduce ICP, and compared with the other two methods, rapid infusion has a shorter onset time, a longer maintenance time, and a significantly greater effect in reducing ICP.