复方金思维醇提液包合工艺研究

Study on the β-cyclodextrin inclusion process of alcohol extract from the compound JINSIWEI

目的:优选复方金思维醇提液的β-环糊精(β-CD)包合工艺。方法:以醇提液中β-细辛醚为指标性成分,对包合制备过程的影响因素进行考察;以包合物收得率和包合率为指标,采用单因素考察法对其包合工艺进行优化;采用X射线衍射法及差示扫描量热法(DSC)对包合物进行验证。结果:实验结果显示最佳包合工艺为β-CD∶醇提液∶水为3∶1∶5(g∶m L∶m L),包合时间选择3 h;X射线衍射结果及差示扫描量热法结果显示,包合物已形成。结论:该包合方法简单准确,包合条件具有稳定性及适用性,该实验为确定复方金思维醇提液的包合工艺提供了实验依据。

Objective： To establish and optimize the inclusion process of alcohol extract-β-cyclodextein（ β-CD） inclusion. Methods： Selecting β-asaron as index component,the influencing factors were investigated during the inclusion process. Using inclusion rate and yield as the index,the single factor method was conducted to optimize β-CD inclusion technique. The final inclusion compound was verified by X-ray diffraction method and differential scanning calorimetry（ DSC）. Results： The optimized inclusion method was ball milling method and the optimized parameters were as follows： β-CD∶ alcohol extract∶ water = 3 ∶ 1 ∶ 5（ g∶ m L∶ m L）,and milling time = 3 h.X-ray diffraction analysis and DSC showed that alcohol extract existed in the form of inclusion compound.Conclusion： The inclusion method was simple,accurate and the optimum preparation conditions were stable and applicable,which provided experimental basis for determining the inclusion process of the compound JINSIWEI alcohol extract.