YKL-40与慢性鼻-鼻窦炎组织重构的相关性探讨

Relationship between YKL-40 and chronic rhinosinusitis

YKL-40是哺乳类动物类几丁质酶蛋白家族的一员。近年来的多项研究则进一步表明YKL-40在哮喘、关节炎等多种炎性疾病中表达升高,并在疾病的组织重塑中发挥了重要作用。慢性鼻-鼻窦炎(CRS)是鼻-鼻窦黏膜的持续性炎症,主要表现为鼻塞、黏性分泌物、鼻黏膜充血和后鼻滴漏,次要表现为面部压迫感和头痛。CRS的发病机制十分复杂,目前已知炎性反应和组织重构在病理进程中发挥重要作用。在CRS临床分型、诊断和治疗等诸多方面尚存在争议,目前临床上主要依靠鼻内镜检查及CT扫描进行分型诊断,缺乏能在病理生理机制及分子细胞水平深入反映疾病特征的标志物。结合文献探讨YKL-40与慢性鼻窦炎组织重构和炎性反应的相关性以及作为血清标志物的可能性。

YKL-40 is a member of the mammalian chitinase proteins family,also known as chitinase 3-like 1 or cartilage glycoprotein39.In recent years,several studies have demonstrated that YKL-40 is highly expressed in many inflammatory diseases such as asthma,arthritis,and tissue remodeling disease.Chronic rhinosinusitis（CRS） is a persistent inflammation that manifests as nasal congestion,viscous secretions,nasal mucosal hyperemia,and posterior nasal drip,with secondary manifestations of facial pressure and headache.The pathogenesis of CRS is complicated.Inflammatory reactions and tissue remodeling are known to play important roles in the pathological processes of CRS.CRS is controversial in many aspects,such as classification,diagnosis,and treatment.At present,classification mainly depends on clinical diagnosis using,for example,nasal endoscopic examination and computed tomography.No biomarkers that reflect the pathophysiology and characteristics of CRS have been found.This study investigated the correlation of YKL-40 expression with tissue remodeling and the inflammatory reactions in CRS,and the possibility of using YKL-40 as a serum marker.