人血浆脂蛋白与缺血性中风中医证型的关系研究

Discussion on the Relationship Between Lp-PLA2 and the Traditional Chinese Medicine Syndrome of Ischemic Stroke

目的:观察缺血性中风的中医证型与炎性标志物Lp-PLA2水平的关系。方法:参照《中风病辨证诊断标准》将201例缺血性中风患者的进行证候评分,分为痰证和非痰证两种证型;根据这些患者的头颅CT/MRI的结果及临床信息将其分为腔隙性脑梗死/非腔隙性脑梗死、急性缺血性中风/非急性缺血性中风;根据颈动脉B超结果,评价这些患者是否有颈动脉斑块以及斑块稳定性,并对比不同组别患者的Lp-PLA2水平。结果:(1)痰证组的Lp-PLA2水平高于非痰证组(P=0.003)。(2)Lp-PLA2水平随着颈动脉斑块的不稳定而逐渐升高,而且有统计学意义(P=0.02)。结论:Lp-PLA2升高水平可作为判定中医证型痰证与非痰证的微观血清学指标。

Objective： To elucidate the relationship between Lp-PLA2and the TCM syndrome of ischemic stroke. Methods： 201consecutively selected ischemic stroke patients were divided into the phlegm syndrome group and non-phlegm syndrome group according to the standards of syndrome TCM differentiation for stroke. Lp-PLA21evel in different stroke subtype, such as lacuna/ non-lacuna stroke, acute/non-acute stroke, was analyzed with the completely screened brain CT/MRI or clinical information. As with our concerning, the relationship between LP-PLA21evel and carotid artery plaque was also evaluated with emphasis on carot- id artery plaque, plaque stability used B-scan ultrasonography. Results： （1）The levelof Lp-PLA2in the phlegm group was signifi-cantly higher than those in the non-phlegm group （P = 0. 003）. （2）High level of LP-PLA2was observed with the instability of ca- rotid plaque （P=0.02）. Conclusion： Lp-PLA2may be regarded as a serological marker to differentiate the phlegm syndrome from the non-phlegm syndrome in isehemic stroke patients.