中药糊剂在食管癌放疗中减少放射性食管炎的疗效观察

Curative Efficacy of Traditional Chinese Medicine Paste in Preventing and Treating Radiation Esophagitis in Radiotherapy Induced Esophageal Cancer Patients

目的:探讨中药糊剂在食管癌放疗中减少放射性食管炎的疗效。方法:选择2015年1月~2016年10月于我院肿瘤放疗中心接受放疗的85例食管癌患者作为研究对象,按随机数字表法分为治疗组(43例)和对照组(42例)。所有患者均接受同等条件放化疗治疗,放化疗期间对照组给予食管炎常规治疗(利多卡因注射液+地塞米松注射液+庆大霉素注射液),治疗组给予中药糊剂治疗。比较两组患者放射性食管炎的发生率,食管炎的临床疗效以及并发症发生情况。结果:治疗组放射性食管炎总发生率低于对照组总发生率(79.07%<92.86%)(P<0.05);治疗后,治疗组总有效率高于对照组总有效率(91.18%>76.92%)(P<0.05),治疗后,治疗组患者食道干涩、吞咽困难、吞咽疼痛、胸骨后隐痛、胸骨后烧灼感等食管炎症状有所改善;治疗组患者并发症总发生率低于对照组(11.76%<38.46%),差异有统计学意义(P<0.05);其中,治疗组患者食道溃疡发生率明显低于对照组(5.88%<12.82%),差异有统计学意义(P<0.05),治疗组患者食道出血发生率明显低于对照组(2.94%<15.38%),差异有统计学意义(P<0.05),两组患者食道穿孔、食道感染发生率无明显差别,差异无统计学意义(P>0.05)。结论:中药糊剂在食管癌放疗中减少放射性食管炎的防治中临床疗效显著,且不良反应或并发症较轻,值得临床推广。

Objective ： To evaluate the curative efficacy of traditional Chinese medicine paste in preventing and treating radia- tion esophagitis in radiotherapy induced esophageal cancer patients. Methods： 85eases patients with esophageal cancer in our hos- pital from 2015January to 2016October were analyzed, and divided into treatment group （43cases） and controlled group （42cases）. All patients received radiotherapy. During the radiotherapy, the controlled group received conventional treatment （the mixture of dexamethasone, lidocaine, and gentamicin）. The treatment group received traditional Chinese medicine paste. After treatment, the rate of radiation esophagitis, the curative efficacy and the complications were evaluated in the two groups. Results： The rate of radiation esophagitis in the treatment group was obviously lower than the controlled group （79.07% 〈 92.86% ） （P〈0. 05）. The effective rate in the treatment group was obviously higher than the controlled group （91.18% 〉 76.92% ） （ P〈0. 05 ）. Compared with the controlled group, the clinical symptoms of esophageal dry, swallowing pain, swallo- wing difficulties, chest ache, chest burning sensation were relieved in the treatment group. The total rate of complications in the treatment group was obviously lower than the controlled group （ 11.76% 〈38.46% ） （ P〈0. 05 ）. The rate of esophageal ulcers in the treatment group was obviously lower than the controlled group （ 5.88% 〈 12. 82% ） （ P〈0. 05 ）. The rate of esophageal bleed- ing in the treatment group was obviously lower than the controlled group （2. 94% 〈 15.38% ） （P〈0. 05 ）. There were no differ- ences in the esophageal perforation, esophageal infection between the two groups. Conclusion： Traditional Chinese medicine paste used in preventing and treating radiation esophagitis in radiotherapy induced esophageal cancer patients can effectively improve the clinical curative efficacy and reduce the rate of complications, which is worthy of promotion.