摘要
目的探讨急性冠脉综合征(ACS)中医证型分布与Th、Tregs的主要效应分子白细胞介素-17(IL-17)、白细胞介素-35(IL-35)等的相关性。方法共纳入ACS患者143例,于入院当天以ELISA法检测血清IL-17、IL-35,超声心动图Simpson法测定LVEF值。同时进行中医辨证分型及证候积分统计。结果阳气虚证型证候积分最高,气滞血瘀证型分值最低,证型间比较差异有统计学意义(P<0.05)。阳气虚证及痰浊闭塞证IL-35水平较低,而IL-17水平较高,与气滞血瘀证和阴血虚证比较差异有统计学意义(P<0.05),而IL-35与IL-17、LVEF水平在痰浊闭塞与阳气虚证间比较差异无统计学意义(P>0.05);阳气虚证证候积分与IL-17、IL-35及NLR的相关性更明显,而BNP与各证型积分的相关性不明显。结论 ACS患者外周血IL-17、IL-35水平在一定程度上能反映ACS病情严重程度,且在各中医证型间分布呈一定规律,可作为ACS中医辨证分型参考指标。
Objective: To investigation the Th/Tregs main effect molecules IL-17 and IL-35 levels in patients with acute coronary syndrome(ACS) and to explore the correlation between them and the syndrome differentiation of ACS. Methods: 143 cases of eligible subjects were recruited. Serum IL-17 and IL-35 were detected by ELISA,and the electrocardiograph LVEF values were determined by Simpson method. TCM syndrome differentiation and syndrome scores were analyzed at the same time. Results: The syndrome scores of Yangqi deficiency group were the highest,while the Qi stagnation and blood stasis group was the lowest;the difference between them was statistically significant(P〈0.05). The Yang deficiency group and phlegm obstruction group had lower IL-35 levels and higher levels of IL-17;there was statistically significant when compared with the other two groups(P〈0.05),while the difference was not statistically significant in IL-35,IL-17 and LVEF levels in phlegm obstruction and Yangqi deficiency group(P〉0.05). The correlation between syndrome scores and IL-17,IL-35 and NLR of Yangqi deficiency group was more obvious,but the correlation between BNP and the scores of each group was not obvious. Conclusion: The levels of IL-17 and IL-35 in patients with ACS can reflect the severity of the disease to a certain extent,and there is a certain regularity in the distribution of TCM syndromes,which can be used as a reference index of TCM syndrome differentiation of ACS.
作者
余锋
信梦雪
刘南
洪永敦
纪晓栋
刘静
Yu Feng;Xin Mengxue;Liu Nan(The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong , Guangzhou 510405, China)
出处
《中国中医急症》
2018年第7期1175-1177,1189,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
广东省中医药局建设中医药强省科研项目(20161126)
关键词
冠心病
急性冠脉综合征
Th/Tregs
中医药
证型
Coronary heart disease
Acute coronary syndrome
Th/Tregs
Chinese medicine
Syndrome differentiation