小续命汤联合免疫球蛋白对急性格林巴利综合征患者生活活动能力、神经功能缺损程度及CSF蛋白含量的影响

Effect of Xiaoxuming Decoction Combined with Immunoglobulin on the Ability of Activities and Living,the Degree of Nerve Function Deficit and Content of CSF Protein in Patients with Acute Guillian-Barre Syndrome

目的观察小续命汤联合免疫球蛋白对急性格林巴利综合征患者生活活动能力、神经功能缺损程度及脑脊液(CSF)蛋白含量的影响并探讨其机制。方法将104例急性格林巴利综合征患者随机分为两组各52例,对照组应用免疫球蛋白治疗,研究组予小续命汤联合免疫球蛋白治疗,两组均持续治疗2周。比较两组治疗后临床疗效,统计两组治疗前、治疗后3 d、治疗后1周和治疗后2周生活活动能力、神经功能缺损程度及CSF蛋白含量变化情况,记录两组不良反应。结果研究组总有效率为94.23%,显著高于对照组的73.08%(P<0.05)。治疗后3 d、治疗后7 d和治疗后2周,两组生活活动能力评分均较治疗前呈现显著升高趋势(P<0.05),且研究组治疗后各个时间点生活活动能力评分均显著高于对照组(P<0.05);两组斯堪的纳维亚神经功能缺损量表(SSS)评分、CSF蛋白含量均较治疗前呈现显著降低趋势(P<0.05),且研究组治疗后各个时间点SSS评分、CSF蛋白含量均显著低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论小续命汤联合免疫球蛋白治疗急性格林巴利综合征,能明显增强患者生活活动能力,降低神经功能缺损程度,改善CSF蛋白含量。

Objective： To observe the effect of Xiaoxuming Decoction combined with immunoglobulin on the ability of activities and living,the degree of nerve function deficit and content of cerebrospinal fluid（CSF） protein in patients with acute Guillian-Barre syndrome. Methods： 104 patients with acute Guillian-Barre syndrome were randomly divided into two groups. 52 cases in the control group were treated with immunoglobulin,and 52 cases in the study group were treated with Xiaoxuming Decoctioncombined with immunoglobulin;the two groups were treated with continuous treatment for 2 weeks. The clinical efficacy of the two groups after treatment was compared;the changes of the ability of activities and living,the degree of nerve function defect and the content of CSF protein in two groups before treatment,3 days after treatment,1 weeks after treatment and 2 weeks after treatment were observed;the adverse reactions of the two groups were recorded. Results： After treatment,the total effective rate of clinical treatment in the study group was significantly higher than that in the control group（P〈0.05）. 3 days after treatment,7 days after treatment and 2 weeks after treatment,the ability of activities and living scores of the two groups were significantly higher than those before the treatment（P〈0.05）;the scores at every time point of the study group was significantly higher than that of the control group（P〈0.05）;the scores of Scandinavia nerve function defect scale（SSS） and the content of CSF protein in the two groups were significantly lower than those before the treatment（P〈0.05）;the SSS scores and the contents of CSF protein at all time points in the study group were significantly lower than those in the control group（P〈0.05）. During the treatment,there was no significant difference in the incidence rate of adverse reactions between the two groups（P〉0.05）. Conclusion： Xiaoxuming Decoction combined with immunoglobulin on acute Guillian-Barre syndrome can significantly enhance the ability of activities and living of the patients,reduce the degree of nerve function deficit and improve the content of CSF protein.