摘要
侵袭性曲霉病是由致病曲霉菌引起的危及生命的真菌感染,主要致病菌为烟曲霉,而唑类抗真菌药物是临床治疗的首选。目前已上市的唑类抗真菌药物包括伊曲康唑,伏立康唑,泊沙康唑和伊沙康唑。然而,流行病学研究发现曲霉菌对唑类抗真菌药物的耐药率呈逐年上升趋势,给临床治疗造成了威胁。其中,Cyp51A蛋白突变、外排系统高表达以及环境耐药机制等多种因素都参与唑类抗真菌药物的耐药。因此,本文综述近年来有关曲霉菌对唑类抗真菌药物的耐药机制,以期为耐药监测、耐药菌控制和新药研发提供理论依据。
Invasive aspergillosis is a life-threatening mycosis caused by the pathogenic fungus Aspergillus, especially Aspergillus fumigatus. Azole drugs are the treatment of first choice, including itraconazole, voriconazole, posaconazole, and isavuconazole. However, drug resistance monitoring data show that the azole-resistant Aspergillus fungi rate has increased significantly and posed a threat to clinical treatment. The resistance mechanisms include CYP51 protein mutations, overexpression of efflux transporters, and environmentally-derived resistance mechanisms. Here the studies on the resistance mechanisms of Aspergillus fungi resistant to azole are reviewed, in order to provide the theoretical basis for resistance surveillance, control, and drug discovery.
作者
喻玮
楼亚玲
裘云庆
潘红英
Yu Wei;Lou Ya-ling;Qiu Yun-qing;Pan Hong-ying(Department of Infectious Diseases,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310003;State Key Laboratory for Diagnosis and Treatment of Infectious Disease,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003)
出处
《中国抗生素杂志》
CAS
CSCD
2018年第7期801-805,共5页
Chinese Journal of Antibiotics