氟中毒所致神经系统损伤机制研究

Mechanism of nerve injury caused by fluorosis： a review of recent studies

机体在环境中的过量氟暴露可导致多种健康危害，其中神经系统损害尤为严重。已经有大量实验及临床资料证实，摄人环境中过量的氟会引起神经毒性，并产生一系列中枢神经系统功能障碍的症状。通过对近年来氟中毒引起神经毒性机制的分析，包括氧化应激、神经递质及受体、中枢神经系统信号分子、神经元能量代谢和糖基化终末产物等方面，阐明氟暴露对神经系统产生影响的原因，从而为氟中毒的进一步防治提供可靠依据。

Excessive exposure to fluoride in the environment leads to a variety of health hazards, especially in the nervous system damage. Great number of experimental and clinical data have confirmed that excessive intake of fluoride can cause neurotoxicity, and produce a series of symptoms of central nervous system dysfunction. This review summarizes the mechanisms of neurotoxicity induced by fluorosis in recent years, including oxidative stress, neurotransmitters and receptors, central nervous system signaling molecules, neuronal energy metabolism, and glycosylation end products. This paper analyzes the effects of fluorine exposure on nervous system, thus providing a reliable basis for further prevention and treatment of fluorosis.