银川市中小学生血清25-羟维生素D水平

Serum vitamin D levels among primary and middle school students in Yinchuan

目的了解银川市中小学生血清25-羟维生素D水平,为预防中小学生维生素D缺乏与不足,合理补充维生素D提供依据。方法在银川市兴庆区和金凤区随机抽取小学和初中,采用分层整群抽样的方法抽取研究对象1 458名。采用酶联免疫吸附法(ELISA法)测定血清25-羟维生素D浓度。结果银川市中小学生血清25-羟维生素D浓度中位数为52.93 nmol/L,四分位数间距为59.37 nmol/L,其中充足者784名(53.77%),缺乏者461名(31.62%),不足者213名(14.61%),未见过量和中毒者。不同年龄组间血清25-羟维生素D水平、缺乏与不足检出率比较,差异均有统计学意义(P值均<0.05)。缺乏检出率各年龄段均较高,尤其以12岁组最高(43.3%)。不足检出率以7岁组最高(16.8%),8~12岁随年龄增长呈升高趋势,13岁开始逐渐降低。不同性别、民族间血清25-羟维生素D水平、营养状况分布比较差异均无统计学意义(P值均>0.05)。结论银川市中小学生血清25-羟维生素D虽总体平均水平处于适宜状态,但是维生素D缺乏、不足检出率仍较高。应进行合理的干预和加强户外活动。

Objective To investigate the serum vitamin D levels among primary and middle school students in Yin chuan,and to provide a scientific reference for vitamin D supplementary recommendation. Methods Stratified cluster sampling method was used to extract classes from randomly selected primary and middle schools in Xingqing and Jinfeng District of Yinchuan. According to the relevant inclusion criteria and exclusion criteria, 1 458 primary and middle school students were selected. The concentration of serum 25（ OH） D was determined by enzyme-linked immunosorbent assay（ ELISA）. Results The serum 25（ OH） D concentration among 1 458 primary and middle school students was 52. 93 nmol/L, the interquartile distance was 59. 37 nmol/L. 784（ 53. 8%）students were classified as sufficient, 461（ 31. 6%） deficient, and 213（ 14. 6%） insufficient. The average level of serum 25-hydroxyvitamin D and prevalence of insufficient and deficiency differed in age（ P〈0.05）. Serum 25-hydroxyvitamin D deficiency was common across all age groups, especially in the 12 year old group（ 43.3%）, while insufficiency prevalence was highest in the 7-year-old group（ 16. 8%）. Serum 25-hydroxyvitamin D concentration showed an upward trend since 8 years old and gradually decreased at the age of 13. No significant differences in serum 25-hydroxyvitamin D concentration, as well as insufficient and deficiency prevalence were found in gender and ethnicity. Conclusion The serum 25-hydroxyvitamin D level among primary and middle school students in Yinchuan remains low and vitamin D deficiency remains high. It is important to ensure appropriate intervention and outdoor activities.