高血压患者尿酸、总胆固醇与动态动脉硬化指数的关系

Relationship between uric acid,total cholesterol and ambulatory arterial stiffness index in hypertensive patient

目的探讨血清尿酸、血脂等生化指标与动态动脉硬化指数（AASI）之间的关系。方法从2011年1月至6月在阜外医院进行24 h动态血压监测与血清生化指标检测,且均未服用过降压药物的疑诊高血压患者中,纳入280例研究对象。AASI根据24 h动态血压计算,计算方法为1-（24 h舒张压对收缩压的回归系数）,采用Pearson相关分析和逐步多因素线性回归分析AASI与生化指标的关系。结果 280例研究对象平均年龄为50.4±13.3岁,其中男性161例,高血压患者138例;Pearson相关分析显示,高血压组中,AASI与血清尿酸（r=0.168,P=0.049）、总胆固醇（r=0.269,P=0.001）、低密度脂蛋白胆固醇（r=0.223,P=0.009）水平均呈正相关;多因素线性回归分析表明高血压患者AASI与血清尿酸（β=0.219,P=0.007）、总胆固醇（β=0.226,P=0.005）水平均呈正相关。结论高血压患者血清尿酸、总胆固醇与AASI正相关。

Aim To investigate the relationship between uric acid,blood lipids and ambulatory arterial stiffness index（ AASI）. Methods A total of 280 subjects without taking anti-hypertensive medication from Fuwai Hospital during January to June,2011 were enrolled. Ambulatory blood pressure monitoring（ ABPM） and blood biochemical examination were performed among all subjects. AASI was calculated as 1 minus the regression coefficient of diastolic blood pressure on systolic blood pressure according to ABPM recordings. Pearson correlation analysis and stepwise multivariable linear regression models were used to assess the relationships between AASI and biomarkers. Results Among 280 subjects,161 were men,138 were hypertensive,and the average age was（ 50.4±13.3） years old. Pearson correlation analysis indicated that AASI was related to serum uric acid（ r = 0.168,P = 0.049）,total cholesterol（ r = 0. 269,P = 0. 001）,low-density lipoprotein cholesterol（ LDLC）（ r = 0. 223,P = 0. 009） in hypertensive participants. Stepwise multivariable linear regression analysis indicated that AASI was independently associated with serum uric acid（ β = 0. 219,P = 0. 007）and total cholesterol（ β = 0.226,P = 0.005） in hypertensive participants. Conclusion Serum uric acid and total cholesterol are independently correlated to AASI in hypertensive patients.