CD36的结构、功能调节及其在动脉粥样硬化中的作用

The structure and functional regulation of CD36 and its role in atherosclerosis

CD36是一种多功能跨膜糖蛋白,介导细胞对氧化型低密度脂蛋白（ox-LDL）的摄取,诱导单核细胞转化为泡沫细胞,并通过炎症反应、氧化应激、血小板活化、巨噬细胞捕获促进动脉粥样硬化形成。抑制CD36的表达或干扰其相关信号通路可以显著缓解动脉粥样硬化的严重程度。另外,舌、鼻腔、小肠和大脑的CD36高表达可促进机体对脂质摄入和吸收,增加代谢性疾病的疾病危险因素。血清可溶性CD36是循环微粒的组分,且可能是心血管疾病的预测因子。

CD36 is a multifunctional transmembrane glycoprotein that binds to oxidized low density lipoprotein to induce monocyte transformation into foam cells and promotes the formation of atherosclerosis through inflammatory response,oxidative stress,platelet activation,macrophage trapping. Inhibition of CD36 expression or interference with its associated signaling pathways can significantly alleviate the severity of atherosclerosis. In addition,the high expression of CD36 in the tongue,nasal cavity,small intestine and brain promotes the body＇s intake and absorption of lipids,and increases the risk factors of metabolic diseases. Serum soluble CD36 is found as a component of circulating microparticles and may be as a predictor for atherosclerotic disease.