“新宠”外泌体正式进入临床检验，路还有多远？

Exosomes, the novel biomarkers, are being used in clinical examinations. When will they be available

外泌体是由细胞内囊泡与细胞膜融合后分泌到细胞外环境的纳米级囊泡。越来越多的证据表明外泌体是可以用作肿瘤和其他疾病诊断和预后判断的生物学标志物。但外泌体检测标准化工作在国内外仍处于起步阶段，检测结果的一致性和准确性亟待解决，在精准医学时代挑战和机遇并存。本文回溯外泌体检测的兴起过程，剖析外泌体检测在临床检验普及中所面临的挑战。（手华检验医学杂志．2018．41：487-490）

Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the cell membrane. A growing body of evidence suggests that exosomes may be used as biomarkers for the diagnosis and prognosis of malignant tumors and other pathologies. At present, the standardization of exosomes detection at home and abroad is still in primary stage. The consistency and accuracy of measurement results for exosomes are needed to be solved urgently. In the era of precision medicine, exosomes detection will continue to have significant impacts on laboratory medicine, in spite of the inherent challenges posed by the technology. This article reviews the exosomes detection development course and illustrates the challenges of appropriately applying exosomes detection to clinical diagnostics. （ Chin J Lab Med, 2018, 41：487-490）