老年低血糖患者血浆tau蛋白、ptau蛋白与认知功能关系的研究

Relationship between plasma tau protein,ptau protein level and cognitive function in elderly patients with hypoglycemia

目的 探讨血浆tau蛋白、ptau蛋白与老年低血糖患者认知功能的关系。方法 选取2014年1月至2017年1月于连云港市第二人民医院老年医学科就诊的老年低血糖患者136例。根据AD8量表及简易智能精神状态检查量表(MMSE)测评结果分为认知功能障碍(CI)组及对照(Con)组,每组各68例。两组进行tau蛋白、ptau蛋白含量测定。结果 CI组FPG水平低于Con组[(3.01±0.96)vs(3.56±0.61)mmol/L,P<0.05];低血糖持续时间高于Con组[(120.61±80.37)vs(30.58±22.34)min,P<0.05];tau蛋白、ptau蛋白水平均高于Con组[(195.57±63.14)vs(125.16±49.35)pg/ml、(79.35±13.85)vs(40.53±16.91)pg/ml,P<0.05]。tau蛋白、ptau蛋白与血糖、低血糖持续时间无相关性(P>0.05),与MMSE呈负相关(P<0.05)。结论 血浆tau蛋白、ptau蛋白水平在一定程度上可反映老年低血糖患者认知功能受损程度。

Objective To investigate the relationship between plasma tau protein,ptau protein and cognitive function in the elderly with hypoglycemia. Methods A total of 136 elderly patients with hypoglycemia were selected in this study from January 2014 to January 2017 in the Department of Geriatrics,Second People＇s Hospital of Lianyungang.All the patients were divided into two groups according to the results of AD8 and MMSE：patients with cognitive impairment（CI group,n=68）and patients without cognitive impairment（Con group,n=68）.Tau protein and ptau protein levels were tested in all the subjects. Results The level of glucose was significantly lower in CI group than in Con group[（3.01±0.96）vs（3.56±0.61）mmol/L,P〈0.05].The duration of hypoglycemia was significantly longer in CI group than in Con group[（120.61±80.37）vs（30.58±22.34）min,P〈0.05].The levels of tau protein and ptau protein were significantly higher in CI group than in Con group[（195.57±63.14）vs（125.16±49.35）pg/ml,（79.35±13.85）vs（40.53±16.91）pg/ml,P〈0.05].Tau protein and ptau protein had no significant correlation with hypoglycemia or duration of hypoglycemia（P〉0.05）.Tau protein and ptau protein were negatively correlated with MMSE（P〈0.05）. Conclusion Plasma tau protein and ptau protein levels can reflect the degree of cognitive impairment in elderly patients with hypoglycemia.