莫西沙星联合用药治疗老年重症肺炎疗效观察及对细菌清除率的影响

Clinical Observation on Combined Use of Moxifloxacin in the Treatment of Elderly Patients with Severe Pneumonia and Its Effect on Bacterial Clearance

目的探讨莫西沙星联合用药治疗老年重症肺炎的临床疗效及对细菌清除率的影响。方法选取医院2015年10月至2017年3月收治的老年重症肺炎患者92例,采用随机数字表法分为对照组和观察组,各46例。对照组患者静脉滴注头孢哌酮钠舒巴坦钠治疗,观察组患者加用静脉滴注莫西沙星治疗,两组患者均治疗7～14 d。结果观察组患者治疗总有效率为93.48%,明显高于对照组的71.74%(χ~2=7.57,P=0.00);观察组患者的肺部炎症、症状体征、发热、痰液颜色及白细胞计数恢复至正常时间明显短于对照组(P<0.01);观察组细菌清除率为78.43%,明显高于对照组的59.18%(χ~2=4.33,P=0.03);两组患者不良反应发生率相当(6.52%比10.87%,P>0.05)。结论莫西沙星联合用药治疗老年重症肺炎的疗效显著,可促进患者症状和体征改善,提高细菌清除率,不良反应较少,值得推广。

Objective To investigate the effect of combined use of moxifloxacin in the treatment of elderly patients with severe pneumonia and its effect on bacterial clearance. Methods Totally 92 elderly patients with severe pneumonia admitted to our hospital from October 2015 to March 2017 were selected and randomly divided into the control group and the observation group, 46 cases in each group. The control group was given intravenous infusion of cefoperazone sodium and sulbactam sodium, on this basis, the observation group was treated with intravenous infusion of moxifloxacin. The two groups were treated for 7-14 d. Results The total effective rate of the observation group was 93. 48%, which was significantly higher than 71. 74% of the control group（ χ~2= 7. 57, P = 0. 00）. The symptoms and signs of pulmonary inflammation, fever, sputum color and white blood cell count（ WBC） returned to normal time in the observation group were significantly shorter than those in the control group（ P〈0. 01）. The bacterial clearance rate of the observation group was 78. 43%, which was significantly higher than 59. 18% of the control group（ χ~2= 4. 33, P = 0. 03）. There was no significant difference in the incidence rate of adverse reactions between the two groups（ 6. 52% vs. 10. 87%, P〈0. 05）. Conclusion The combined use of moxifloxacin in the treatment of elderly patients with severe pulmonary has a significant effect, it can effectively improve the symptoms and signs of the patients,improve the bacterial clearance rate,and has less adverse reactions. It is worthy of promotion.