胸腺五肽联合CAG方案治疗老年急性髓系白血病30例临床观察

Clinical Observation on Thymopentin Combined with CAG Regimen in the Treatment of Elderly Patients with Acute Myeloid Leukemia in 30 Cases

目的探讨胸腺五肽联合CAG方案[阿糖胞苷(Ara-C)+阿克拉霉素(ACR)+粒细胞集落刺激因子(G-CSF)]治疗老年急性髓系白血病(AML)的疗效。方法选取医院就诊的老年AML患者60例,随机分为常规CAG方案治疗组(对照组)和胸腺五肽联合CAG方案治疗组(研究组),各30例,均治疗2个疗程。结果两组均有疗效,但对照组治疗总有效率显著低于研究组(P<0.05);与对照组相比,研究组患者的血清白细胞介素2(IL-2)水平明显降低(P<0.05);化学治疗期间,研究组肺部感染的发生率明显减少(P<0.05),其余不良反应无明显差异(P>0.05)。结论胸腺五肽联合CAG方案治疗老年AML疗效好,能明显改善患者免疫功能,降低肺部感染的发生率,值得临床推广。

Objective To investigate the effect of thymopentin combined with CAG regimen [ arabinosylcytosine（ Ara-C）, aclarubicin（ ACR） combined with granulocyte colony-stimulating factor（ G-CSF） ] in the treatment of elderly patients with acute myeloid leukemia.Methods Totally 60 elderly patients with acute myeloid leukemia admitted to our hospital were selected and randomly divided into the control group（ treated with conventional CAG regimen） and the study group（ treated with thymopentin combined with CAG regimen）, 30 cases in each group. The two groups were treated for 2 courses. Results The patients in the two groups had clinical effects,but the total effective rate of the control group was significantly lower than that of the study group（ P〈0. 05）. The serum IL-2 level of the study group was significantly lower than that of the control group（ P〈0. 05）. During chemotherapy,the incidence rate of lung infection in the study group was significantly reduced（ P〈0. 05）, there was no significant difference in other adverse reactions between the two groups（ P〉0. 05）. Conclusion Thymopentin combined with CAG regimen is effective in the treatment of elderly patients with acute myeloid leukemia, it can significantly improve the immune function of patients, reduce the incidence of lung infection, which is worthy of clinical promotion.