肠缺血-再灌注损伤机制、预防和治疗

Intestinal ischemia-reperfusion injury: its mechanism, precaution and management

肠缺血性疾病易导致肠缺血-再灌注(I-R)损伤。肠I-R损伤机制涉及肠黏膜上皮细胞内线粒体损伤、自由基累积、Ca^(2+)超载,肠黏膜局部炎性反应及肠黏膜上皮细胞的凋亡等。预防措施包括缺血预处理和缺血后处理。治疗方法包括能量疗法、抗氧自由基疗法、抗白细胞黏附疗法等。了解肠I-R损伤机制,及时予以有效的预防和治疗措施是降低肠I-R损伤患者高死亡率的关键。

Intestinal ischemic disease may lead to intestinal ischemia-reperfusion （I-R） injury. The mechanism of intestinal I-R injury involves mitoehondrial damage, accumulation of free radicals, overload of Ca2＋, local inflammatory response of intestinal mucosa, the apoptosis of intestinal mucosal epithelium, etc. The preventive measures for I-R injury include pre-treatment of ischemia and post- ischemie treatment. Therapies for I-R injury include energy therapy, anti-oxygen free radical therapy, anti-leukocyte adhesion therapy, etc. Fully understanding the mechanism of intestinal I-R injury and timely taking effective preventive and therapeutic measures are the key to reduce the high mortality rate of patients with intestinal I- R injury.