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核仁小RNA在肿瘤发生发展中的研究进展

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摘要 非编码RNA(ncRNA)是涉及多种细胞重要生理过程的调控分子。ncRNA,特别是微RNA(miRNA),在肿瘤发生发展过程中起着至关重要的作用。越来越多的证据表明,核仁小RNA(snoRNA)的失调与肿瘤相关。snoRNA可能作为抑制基因或原癌基因参与肿瘤的发生发展,并且snoRNA相关基因印记及应激反应也与疾病的发生有关。snoRNA是核苷酸数量为60~300的小分子非编码RNA,由内含子编码。大量的研究表明,snoRNA的作用机制为核糖体RNA(rRNA)的2'-O-甲基化及rRNA的假尿苷化,snoRNA调控紊乱可导致疾病的发生。本文介绍了snoRNA的相关功能及其在肿瘤诊断、治疗中的可能应用。
作者 胡江平 贺更生
机构地区 南华大学附属第一医院肝胆脾胰外科
出处 《癌症进展》 2018年第7期816-819,共4页 Oncology Progress
关键词 NCRNA 核仁小RNA 肿瘤 诊断 治疗 预后
分类号 R730.2 [医药卫生—肿瘤]
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癌症进展
2018年 第7期

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