比索洛尔联合瑞舒伐他汀对老年冠心病心绞痛患者左心射血分数及血清NT-proBNP、CK-MB水平的影响

Effects of bisoprolol combined with rosuvastatin on left ventricular ejection fraction and levels of serum NT-proBNP and CK-MB in elderly patients with coronary heart disease and angina pectoris

目的研究老年冠心病心绞痛患者以比索洛尔联合瑞舒伐他汀治疗对左心射血分数及血清N端B型脑钠肽前体(NT-proBNP)、磷酸肌酸激酶同工酶(CK-MB)水平的影响。方法选取2015年4月—2017年5月沈阳军区总医院老年冠心病心绞痛患者110例,按随机数字表法分观察组(n=55)、对照组(n=55)。对照组以瑞舒伐他汀治疗,观察组以比索洛尔联合瑞舒伐他汀治疗。对比两组疗效、治疗前后左心射血分数及血清NTproBNP、CK-MB水平、不良反应。结果两组总有效率对比,观察组94.55%高于对照组80.00%(P<0.05);治疗4周后观察组LVEF高于对照组,血清NT-proBNP、CK-MB水平低于对照组(P<0.05);观察组心悸、乏力、头晕、面部潮红等发生率与对照组对比无显著差异(P>0.05)。结论老年冠心病心绞痛患者以比索洛尔联合瑞舒伐他汀治疗效果显著,能有效减轻心肌损伤,改善心功能,且不增加不良反应。

Objective To explore the effect of bisoprolol combined with rosuvastatin on left ventricular ejection fraction and levels of serum N terminal type B brain natriuretic peptide precursor（ NT-proBNP） and creatine kinase isoenzyme（ CK-MB） in elderly patients with coronary heart disease and angina pectoris. Methods From April 2015 to May2016,110 elderly patients with angina pectoris were randomly divided into the observation group（ n = 55） and the control group（ n = 55）. The control group was treated with rosuvastatin,while the observation group was treated with bisoprolol combined with rosuvastatin. The curative effects,left ventricular ejection fraction,levels of serum NT-proBNP and CK-MB and adverse reactions were compared between the two groups. Results In comparison of the total effective rate,the observation group 94. 55% was higher than the control group 80%（ P〈0. 05）. After treatment for 4 weeks,the LVEF of the observation group was higher than that of the control group,and the levels of serum NT-proBNP and CK-MB were lower than those of the control group（ P〈0. 05）. The incidence of palpitation,fatigue,dizziness,facial flushing and others in the observation group wasinsignificantly different from those in the control group（ P〉0. 05）. Conclusion The effect of bisoprolol combined with rosuvastatin in the treatment of elderly patients with coronary heart disease and angina pectoris is significant,which can effectively reduce myocardial injury and improve cardiac function without increasing any adverse reactions.