复脉通阳汤联合常规疗法治疗慢性心力衰竭临床观察

Clinical Observation of Fumai Tongyang Tang Combined with Routine Therapy for Chronic Heart Failure

目的:观察复脉通阳汤联合常规疗法治疗慢性心力衰竭阳虚水泛证的临床疗效。方法:选取200例慢性心力衰竭阳虚水泛证患者,随机分为研究组和对照组各100例。对照组采用常规治疗方案,研究组在对照组基础上加用复脉通阳汤。观察并比较2组治疗前后心功能、中医证候积分、抗氧化能力、超声心动图等指标。结果:治疗后,2组心功能均较治疗前改善(P<0.05),研究组心功能的改善情况优于对照组(P<0.05)。对照组总有效率75.0%,研究组总有效率90.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均较治疗前减小(P<0.05),左心室射血分数(LVEF)、二尖瓣血流频谱(E/A)均较治疗前增大(P<0.05);研究组LVESD、LVEDD均小于对照组(P<0.05),LVEF、E/A均大于对照组(P<0.05)。治疗后,2组丙二醛(MDA)水平均较治疗前降低(P<0.05),过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平均较治疗前升高(P<0.05);研究组MDA水平低于对照组(P<0.05),CAT、SOD、GSH-Px水平均高于对照组(P<0.05)。结论:复脉通阳汤联合常规疗法治疗慢性心力衰竭阳虚水泛证效果显著,能有效改善患者的临床症状,强化心功能,提高抗氧化能力。

Objective： To observe the clinical effect of Fumai Tongyang tang combined with routine therapy for chronic heart failure with edema syndrome due to yang deficiency. Methods： Selected 200 cases of patients with chronic heart failure with edema syndrome due to yang deficiency,and divided them into the study group and the control group randomly,100 cases in each group. The control group was given routine treatment,while the study group was additionally given Fumai Tongyang tang. Observed and compared indexes like heart function,Chinese medicine syndrome scores,antioxidation function and echocardiography in the two groups before and after treatment. Results： After treatment, the heart functions in the two groups were both improved when compared with those before treatment（P〈0.05）,and the improvement of heart function in the study group was better than that in the control group（P〈0.05）.The total effective rate was 75.0% in the control group and was 90.0% in the study group,difference being significant（P〈0.05）. After treatment,left ventricular end diastolic diameter（LVEDD） and left ventricular end-systolic diameter（LVESD） in the two groups were all reduced when compared with those before treatment（P〈0.05）,while left ventricular ejection fraction（LVEF） and the mitral flow pattern（E/A） were increased when compared with those before treatment（P〈0.05）. LVESD and LVEDD in the study group were all lower than those in the control group（P〈0.05）,while LVEF and the E/A was bigger than that in the control group（P〈0.05）. After treatment,the levels of malondialdehyde（MDA） in the two groups were both reduced when compared with those before treatment（P〈0.05）,while the levels of catalase（CAT）, superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） in the two groups were all increased when compared with those before treatment（P〈0.05）. Level of MDA in the study group was lower than that in the control group（P〈0.05）,while levels of CAT, SOD and GSH-Px were all higher than those in the control group（P〈0.05）. Conclusion： Fumai Tongyang tang combined with routine therapy has a significant effect in treating chronic heart failure with edema syndrome due to yang deficiency.It can effectively improve the clinical symptoms of patient,strengthen the heart function and improve the antioxidant capacity.