4-苯基环庚胺的合成研究

Research on the Synthesis of 4-Phenyl cycloheptanamine

以市场易得的4-苯基环己酮为原料,经过与盐酸羟胺缩合得到4-苯基环己酮肟1;再在多聚磷酸作为酸催化剂以及反应溶剂的条件下发生Beckmann重排反应得到4-苯基己内酰胺2;最后用铝锂氢Li Al H4还原酰胺键得到4-苯基环庚胺3,三步反应平均收率为96.3%,总收率为89.4%。该方法具有原料易得,操作简便,产物收率高等优点,可推广合成至该类其它的取代环庚胺衍生物。

Starting from 4-phenylcyclohexanone, 4-phenyl cyclohexanone oxime 1 was obtained through condensation with hydroxylamine hydrochloride, then 4-phenylcycloheptanamide 2 was formed through Beckmann Rearrangement in the catalyst and solvent of polyphosphoric acid PPA. 4-phenylcycloheptanamine 3 was finally obtained by reduction with Li Al H4. The average yield of the three-step reaction was 96.3% and the total yield reached 89.4%. The preparation method has advantages of easy availability of raw materials, simple operation and high yield of the product, and can be applied the other substituted cycloheptanamine derivatives.