弹力袜预防下肢静脉血栓形成后综合征的Meta分析

Effect of elastic socks in the prevention of venous thrombosis syndrome in patients with lower limb： a Meta-analysis

目的评价弹力袜预防静脉血栓形成后综合征的效果以及对静脉血栓复发和相对死亡风险的影响。方法检索PubMed、EMBASE、Cochrane Library、CNKI和万方数据资源系统中关于弹力袜应用于静脉血栓形成后综合征的随机对照试验（RCT），检索时限均从建库到2017年7月1日，以RevMan5．3软件进行统计分析。结果共纳入7篇RCT（n=I571）。结果显示，弹力袜对静脉血栓形成后综合征具有预防作用（OR=0．46，95％CI：0．24-0．87，P=0．02）；对预防静脉血栓复发（OR=0．76，95％CI：0．48-1．20，P=0．24）和患者相对死亡风险（RR=0．99，95％CI：0．72-1．36，P=0．94）无显著影响。结论弹力袜能预防静脉血栓形成后综合征，是一种安全有效的护理措施，建议临床上推广使用；而弹力袜对静脉血栓复发和相对死亡风险无影响。

Objective To evaluate the effect of elastic socks in the prevention of venous thrombosis syndrome, the recurrence of venous thrombosis and the relative risk of death. Methods The databases of PubMed, EMBASE, Cochrane library, CNKI, Wanfang were searched for randomized controlled trials （RCT） of application of elastic socks in the venous thrombosis syndrome. The retrieval time was from the inception date to July 1st, 2017. Revman 5.3 software was used to perform Meta-analysis. Results A total of 7 RCTs （n= 1 571） were included in the study. The data analysis showed that elastic socks had a preventive effect on venous thrombosis syndrome （OR=0.46, 95%CI： 0.24-0.87, P=0.02） ; it had no significant effects on the prevention of recurrent venous thrombosis and the relative risk of death （OR=0.76, 95%CI： 0.48-1.20, P=0.24; RR=0.99, 95%CI： 0.72-1.36, P=0.94）. Conclusions Elastic socks is a safe and effective nursing measure, which can prevent venous thrombosis syndrome, and is recommended to promote the clinical practice. In addition, the elastic socks have no effect on the prevention of recurrent venous thrombosis and the relative risk of death.