福辛普利治疗冠心病的效果及对冠脉血流储备的影响

Effect of Fosinopril on Coronary Heart Disease and Its Effect on Coronary Flow Reserve

目的观察福辛普利对冠心病的治疗效果及对冠脉血流储备的作用。方法选择2015年~2018年于我院内科就诊的78例冠心病患者,将这78名患者随机分配为观察组和对照组,每组39例。观察组的患者服用福辛普利;对照组患者服用安慰剂,治疗疗程为两个月。两个月后,分别观察两组患者的冠心病病情及有关冠脉血流储备指标有无变化,并进行比较。结果经两个月治疗,观察组的心率(HR)、左室收缩末内径(LVESD)、左室舒张末内径(LVEDD)和心功能等级这四项指标均低于对照组,而左心射血分数(LVEF)这一指标经治疗高于对照组。该五项指标差异明显(P<0.05)。结论福辛普利可有效治疗冠心病并能够改善冠脉的血流储备情况,基于此,建议临床推广使用。

Objective To observe the effect of fosinopril on coronary heart disease and its effect on coronary flow reserve. Methods A total of 78 patients with CAD who were admitted to our department from 2015 to 2018 were selected. The 78 patients were randomly assigned to the observation group and the control group, with 39 cases in each group. Patients in the observation group took fosinopril; patients in the control group took placebo for two months. Two months later, the status of coronary heart disease and changes in coronary flow reserve were observed in two groups of patients and compared. Resu Its After two months of treatment, the four indicators of heart rate （HR）, left ventricular end-systolic diameter （LVESD）, left ventricular end diastolic diameter （LVEDD）, and cardiac function were lower in the observation group than in the control group. The index of ejection fraction （LVEF） was treated higher than the control group. The five indicators were significantly different （P〈0.05）. Conclusion on Fosinopril can effectively treat coronary heart disease and improve the coronary flow reserve. Based on this, it is recommended to use it clinically.