Akt下游蛋白调控炎症介质表达机制的研究进展

Research advance in the mechanism of Akt downstream protein regulation of inflammatory mediators

磷酸肌醇3-激酶(PI3K)/丝氨酸苏氨酸蛋白激酶(Akt)信号通路是生物体内重要的信号通路之一,能够调控细胞生长、增殖、凋亡等生物活性。大量研究表明PI3K/Akt信号通路激活可以参与炎症反应、调节免疫应答。Akt是PI3K信号通路的关键下游蛋白,因此研究Akt下游蛋白对休克、脓毒症、缺血再灌注损伤等炎性疾病调控的作用机制,有助于找到治疗该类疾病的潜在靶点。

Phosphoinositol 3-kinase（PI3K）/serine threonine protein kinase（Akt）signaling pathway is one of the important signaling pathways in the body,which can regulate the biological activity of cell growth,proliferation and apoptosis. A large number of studies have shown that activation of PI3K/Akt signaling pathway is involved in inflammatory responses and regulation of immune responses. Akt is a key downstream protein of the PI3 K signaling pathway. Therefore,the mechanism of Akt downstream protein on the regulation of inflammatory diseases such as shock,sepsis and ischemia-reperfusion injury is helpful to find a potential target for the treatment of these diseases.