牙周组织工程新技术的研究进展

Development of new technology in periodontal tissue engineering

由牙周炎等疾病导致的牙周支持组织丧失将引起牙齿逐渐松动脱落，进而影响发音和进食，甚至导致一系列生理和心理问题。组织工程作为可实现组织器官重塑及功能重建的技术，已在牙周组织再生中取得可喜成绩，但传统的构建方法在实现功能性牙周再生方面仍存在诸多不足。随着组织工程技术的进步，近年来涌现了一系列新技术、新方法，如细胞膜片技术、脱细胞技术、静电纺丝技术、三维打印技术等，为牙周组织再生带来新的希望。本文对近年来牙周组织工程领域取得的新进展及应用的新技术进行简要阐述，以期探讨未来牙周再生的发展方向。

The loss of periodontal support tissues might cause movement or finally loss of the teeth affected, impair furthermore the pronunciation and mastication functions, and even result in a series of physiological and psychological problems. Tissue engineering, as a technology to remodel missing tissues or organs and functional reconstruction, has achieved gratifying progress in regeneration of periodontal tissues. However, conventional construction methods have some deficiencies for functional periodontal reconstruction. In recent years, with the progress of tissue engineering technology, a series of new techniques and methods, such as cell sheet technology, decellular technology, electrospinning technology and three-dimensional printing, has been applied in tissue engineering bringing new hope for the regeneration of periodontal tissues. In this review article, the recent progress achieved in the field of periodontal tissue engineering and application of modern technology are summarized to make a brief exposition and to explore the future development of periodontal regeneration.