脾氨肽冻干粉对儿童反复呼吸道感染的临床疗效及对免疫功能的影响

Effects of polypeptide lyophilized powder of the spleen combined with conventional therapy in children with recurrent respiratory tract infection

目的探讨脾氨肽冻干粉对儿童反复呼吸道感染的治疗效果以及药物对患儿免疫功能产生的影响。方法自2012年1月至2016年12月间，将西安市中心医院儿科收治的小儿反复呼吸道感染者116例作为研究对象，按照数字随机表法分为研究组和对照组各58例，对照组患儿给予常规抗感染治疗，研究组患儿在常规治疗的基础上联合使用脾氨肽冻干粉进行治疗，观察两组患儿的临床效果以及免疫功能变化情况。结果研究组患儿临床总有效率为94.83%，明显高于对照组的77.59%，差异具有统计学意义（P〈0.05）；治疗后两组患儿免疫球蛋白（immunoglobulin，Ig）A、IgG、IgM和C3等指标水平均明显升高，其中研究组患儿升高水平均明显优于对照组，差异具有统计学意义（P〈0.05）；治疗后研究组患儿CD3＋、CD4＋、CD4＋/CD8＋明显升高，CD8＋明显降低，改变程度明显优于对照组，差异具有统计学意义（P〈0.05）。结论在常规治疗的基础上联合脾氨肽冻干粉治疗儿童反复呼吸道感染可提高患儿临床治疗总有效率，改善患儿免疫功能各项指标，效果明显，可在临床范围内推广使用。

ObjectiveTo investigate the effect of spleen polypeptide lyophilized powder in the treatment of recurrent respiratory tract infection and the effects of drugs on the immune function of children.MethodsFrom January 2012 to December 2016, 116 childrens with recurrent respiratory tract infection were collected in Xi＇an Central Hospital.All Subjects were divided into control group and research group randomly, 58 cases in each group.The patients in the control group were treated with conventional anti infection treatment and patients in the research group were treated with spleen polypeptide lyophilized powder on the basis of conventional therapy.The clinical effect and the changes of immunoglobulin were compared between the two groups.ResultsThe research group had a clinical total effective rate（ 94.83%）, which was significantly higher than control group （ 77.59%）, and the difference was statistically significant （P〈0.05）. The expression level of immunoglobulin（Ig）A, IgG, IgM and C3 were significantly increased in both groups after treatment, the research group was significantly better than the control group, the difference was statistically significant （P〈0.05）. After treatment the levels of CD3＋ , CD4＋ and CD4＋ /CD8＋ increased and CD8＋ decreased significantly in research group, which was better than the control group, the difference was statistically significant（P〈0.05）. ConclusionPolypeptide lyophilized powder of the spleen combined with conventional therapy is an effective and safe agent for treatment of respiratory tract infection, which can improve the clinical effect and the immune function of children.The method is worth of further application in clinical treatment.