吸烟与种植体周围炎发病风险相关性Meta分析

The correlation between smoking and the risk of peri-implantitis:a Meta-analysis

目的系统评价吸烟与种植体周围炎发病的相关性,为进行人群健康教育和预防决策提供依据。方法计算机检索Pub Med、Embase、Cochrane library、中国知网(CNKI)、万方、维普、Sino Med等数据库,查找吸烟与种植体周围炎发病风险的病例对照研究,由2名评价员独立按照纳入与排除标准选择文献、提取资料和评价质量后,采用Rev Man5.3软件对符合纳入标准的研究进行Meta分析,合并其比值比(OR)和95%可信区间(CI)并对发表偏倚进行漏斗图分析。结果共纳入9个病例对照研究,包含3674例患者。方法学质量评价结果显示纳入研究总体研究质量较高。Meta分析结果显示,与不吸烟人群相比,吸烟人群发生种植体周围炎的可能性显著增加[OR=2.93,95%CI:2.19~3.91,P<0.05],吸烟组和非吸烟组种植体周围炎发病率差异有统计学意义。结论吸烟与种植体周围炎发生呈正相关,是发生种植体周围炎的危险因素,相对于不吸烟的种植患者而言,吸烟使种植体周围炎发生风险增高了1.93倍。

Objective To systematically assess the correlation between smoking and the risk of peri-implantitis,so as to offer scientific basis for health education and preventve decision. Methods A literature search was performed in Pubmed,Embase,Cochrane Library,CNKI,Wanfang,VIP and Sino Med database to collect the case control studies on the correlation between smoking and peri-implantitis. Two reviewers independently screened the literatures according to the inclusion and exclusion criteria,extracted the data,assessed the quality,and then conducted Meta-analyses on the included studies by using Rev Man 5.3 software,with calculation of the OR value and 95%CI. Results A total of 9 case control studies involving 3674 cases were included. The quality assessment indicated that studies were generally of high quality. Meta-analyses showed that compared with non-smokers,there was increasing possibility of peri-implantitis in smokers[OR = 2.93,95%CI：2.19~3.91,P〈0.05]. Conclusion There is a positive correlation between smoking and periodontal inflammation,smoking is one of the risk factors of peri-implantitis. Smoking increases the risk of peri-implantitis by 1.93 times compared with non-smoking patients