染色体9p21多态性位点rs2383206与中国汉族人群冠心病的meta分析

Association studies between the SNP rs2383206 on chromosome 9p21 and coronary artery disease in Chinese han population：a meta-analysis

目的：分析中国汉族人群中染色体9p21基因多态性位点rs2383206与冠心病的相关性分析。方法：以PubMed、EBSCO、CNKI等为搜索数据库，检索从建库到2018年2月发表有关中国地区汉族人群染色体9p21多态性位点rs2383206与冠心病相关性的随机病例对照研究，并用stata12．0软件进行统计meta分析比较。结果：11篇文献符合条件，Meta分析结果显示中国汉族人群染色体9p21．3单核苷酸多态性位点rs2383206与冠心病存在明显相关性，OR=1．18（95％Cl,1．10-1．26，P=0．00）。结论：中国汉族人群染色体9p21单核苷酸多态性位点rs2383206与冠心病发病风险增高相关，其中G等位基因可能为冠心病的危险因子。

Objective： This study aims to clarify the exact relationship of the the SNP rs2383206 in chromosome 9p21 with coronary artery disease in Chinese han people. Methods： All Original case-control studies published about the chromosome 9p21 rs2383206 and coronary artery disease were discovered through PubMed, EBSCO and CNKI fill February 2018 in chinese han people. Furthermore, all seligible case control studies were Meta-analysis conducted on Stata 12.0 software. Results： 11 eligible articles were included. The results of Meta-analysis indicated that the SNP rs2383206 of chromosome 9p21 was significantly associated with the coronary artery disease in chinese han people, and the summary OR was 1.18 （95%Cl, 1.10-1.26, P=0.00）. Conclusion： The SNP rs2383206 of chromosome 9p21 correlated with coronary artery disease susceptibility, and allele G may be the predisposing gene.