血清LPS、PCT联合检测对脓毒血症的诊断价值

The diagnostic value of combined detection of serum endotoxin and procalcitonin for sepsis

目的：探讨血清内毒素和降钙素原联合检测对脓毒血症的诊断价值。方法：选取2016年1月-2017年5月苏州大学附属第三医院ICU的97例患者作为研究对象，健康成年人60例为正常对照组，对所有人群的血清LPS、PCT进行检测。结果：脓毒症组LPS与PCT的联合检测阳性率为60．％，明显高于非脓毒症组联合检测阳性率23．5％，差异有统计学意义（P〈0．05）；联合检测的特异性（76．5％）和灵敏度（39．1％）明显高于单项检测。结论：血清LPS、PCT联合检测更有助于临床医师早期诊断脓毒症患者。

Objective： To investigate the value of combined detection of serum endotoxin and procalcitonin in the diagnosis of sepsis. Methods： 97 patients in the ICU department of the Third Affiliated Hospital of Suzhou University from January 2016 to May 2017 were selected as the subjects of study, and 60 healthy adults were chose as the normal control group. The serum LPS and PCT levels were detected. Results： The positive rate of combined LPS and PCT in the sepsis group （60.9%） was significantly higher than that in the nonsepsis group（23.5%）, the difference was significant （P〈0.05） ; The specificity and sensitivity of combined detection （76.5%, 39.1%） were significantly higher than those of single detection. Conclusion： The combined detection of serum LPS and PCT is more helpful for clinicians to diagnose and treat sepsis at early stage.