高频重复经颅磁刺激对脊髓小脑性共济失调3型(SCA3)患者运动症状的疗效评估

Efficacy of high-frequency repetitive transcranial magnetic stimulation on motor symptoms in patients with Spinocerebellar ataxia 3(SCA3)

目的:观察高频重复经颅磁刺激对脊髓小脑性共济失调3型(SCA3)患者运动症状的疗效。方法:将36例SCA3患者随机分为3组:高频A组(接受频率为10Hz的经颅磁刺激)、高频B组(接受频率为5Hz的经颅磁刺激)、伪刺激组(使用无实际刺激作用的伪线圈),刺激部位为双侧小脑半球区域,每周治疗5天,共治疗4周。在基线期、及治疗4周终点使用共济失调等级量表(SARA)对患者运动症状进行评估。结果:经过4周干预,高频A组和高频B组患者SARA量表总分及站立子项得分有明显下降,其治疗前后差值与假刺激组相比有统计学差异(P<0.05);高频A组与高频B组之间无明显差异。结论:高频重复经颅磁刺激可改善SCA3患者部分运动症状,可作为SCA3患者的对症治疗方法。

Objective： To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation（r TMS） on motor symptoms in SCA3 patients. Methods： Thirty-six SCA3 patients were randomly assigned into High Frequency A group, High frequency B group, Sham group（n=12 subjects per group）. Patients received either a frequency of 10 Hz（High Frequency A group）, 5 Hz（High frequency B group）, or sham（Sham group） of stimulation in the bilateral cerebellar hemisphere for 4 weeks（5 times per week）. Motor symptoms were evaluated at baseline, and the end of 4 weeks therapy, using the Scale for Assessment and Rating of Ataxia（SARA）. Results： After 4 weeks of intervention, the total score and the‘stand＇subitem score of SARA were reduced in the High frequency A group and B group（P0.05）, compared with Sham group. No differences were observed between High frequency A group and B group. Conclusions： Application of high-frequency r TMS can improve motor symptoms in SCA3 patients,and may be applied as a symptomatic treatment in SCA3.