锌转运蛋白8抗体阳性的1型糖尿病患者胰岛自身抗体阳性率及生化指标水平

Positive rates of insulin autoantibodies and biochemical indices levels of type 1 diabetes mellitus patients with zinc transporter 8 antibody positive

目的探讨锌转运蛋白8抗体(Zn T-8A)阳性的1型糖尿病(T1DM)患者胰岛自身抗体阳性率及生化指标水平。方法选择T1DM患者52例,分为Zn T-8A阳性组18例和Zn T-8A阴性组34例。检测并对比两组患者胰岛的自身抗体[谷氨酸脱羧酶抗体(GADA)、酪氨酸磷酸酶抗体(IA-2A)、胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)]阳性率及血糖、血脂等指标水平。结果 Zn T-8A阳性组患者的GADA、IA-2A、ICA、IAA阳性率均高于阴性组(P<0.05),但空腹C肽、餐后2 h C肽水水平低于阴性组(P<0.05)。结论 Zn T-8A阳性T1DM患者体内GADA、IA-2A、ICA、IAA等多呈阳性表达,胰岛素分泌功能较差。

Objective To investigate the positive rates of insulin autoantibodies and the levels of biochemical indices in type 1 diabetes mellitus（ T1 DM） patients with zinc transporter 8 antibody（ Zn T-8 A） positive. Methods Fifty-two patients with T1 DM were divided into Zn T-8 A positive group（ n = 18） and Zn T-8 A negative group（ n = 34）. The positive rates of insulin autoantibodies[glutamic acid decarboxylase antibody（ GADA）,protein tyrosine phosphatase autoantibody（ IA-2 A）,islet cell antibody（ ICA）,insulin autoantibody（ IAA） ]as well as the levels of blood glucose and blood lipid were detected and were compared between the two groups. Results In the Zn T-8 A positive group,the positive rates of GADA,IA-2 A,ICA and IAA were all higher than those in the Zn T-8 A negative group（ P〈0. 05）,and the levels of fasting C peptide and 2-hour postprandial C peptide were lower than those in the Zn T-8 A negative group（ P〈0. 05）.Conclusion Most T1 DM patients with Zn T-8 A positive have positive expressions of GADA,IA-2 A,ICA and IAA as well as worse insulin secretory function.