房颤射频消融术后复发影响因素分析

Factors Analysis Affecting Recurrence of Atrial Fibrillation after Radiofrequency Ablation

目的分析房颤射频消融术后复发的影响因素。方法选取2014年5月—2016年12月行射频消融术169例,根据房颤有无复发分为复发组(73例)和未复发组(96例)。比较2组临床资料,分析房颤射频消融术后复发的影响因素。结果复发组病程长于未复发组,N-末端脑钠肽前体(NT-proBNP)水平高于未复发组(P<0.05)。复发组术后3个月超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平高于未复发组,基质金属蛋白酶-9(MMP-9)及缺氧诱导因子-1α(HIF-1α)水平降低程度低于未复发组(P<0.05)。复发组左心房直径、左心房容积(LAVI)大于未复发组(P<0.05)。结论病程、NT-proBNP、hs-CRP、IL-6、MMP-9、HIF-1α、LAVI是房颤射频消融术后复发的影响因素。

Objective To analyze factors affecting recurrence of atrial fibrillation after radiofrequency ablation. Methods A total of 169 patients undergoing radiofrequency ablation during May 2014 and December 2016 were divided into recurrent group （ n = 73 ） and non recurrence group （ n = 96 ） according to whether or not having recurrence of atrial fibrillation. Clinical data was compared, and factors affecting recurrence after radiofrequency ablation for atrial fibrillation were analyzed in two groups. Results In recurrence group, course of disease was significantly longer, and level of N- terminus fragment of probrain natriuretic peptide （NT-proBNP） was significantly higher than those in non recurrent group （P 〈0.05）. In 3 months after surgery, in recurrence group, levels high sensitive C-reactive protein （hs-CRP） and interleukin-6 （IL-6） were significantly higher, while decreased degrees of matrix metalloproteinase-9 （MMP-9） and hypoxia inducible factor-1α （HIF-1α） were significantly lower than those in non recurrent group （ P 〈 0.05 ）. Left atrium diameter and left atrium volume （LAVI） in recurrent group were significantly greater than those in non recurrent group （P 〈 0.05）. Conclusion Course of disease, NT-proBNP, hs-CRP, IL-6, MMP-9, HIF-1α and LAVI are influencing factors of recurrence of atrial fibrillation after radiofrequency ablation.