银杏内酯注射液联合氯吡格雷对老年脑梗死恢复期患者神经功能及预后的影响

Influence of ginkgolide injection combined with clopidogrel on the neurologic function and prognosis of elderly cerebral infarction convalescence patients

目的探讨银杏内酯注射液联合氯吡格雷对老年脑梗死恢复期患者神经功能及预后的影响。方法选取雅安市人民医院2015年5月—2017年5月收治的老年脑梗死恢复期患者80例,根据随机数字表法分为对照组和观察组,各40例。对照组给予氯吡格雷治疗,观察组患者在对照组基础上加用银杏内酯注射液治疗,两组患者均持续治疗2周。比较两组患者治疗前后美国国立卫生院卒中量表(NIHSS)评分、预后及不良反应发生情况。结果治疗前,两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者NIHSS评分低于对照组(P<0.05)。观察组患者预后优于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论银杏内酯注射液联合氯吡格雷治疗老年脑梗死恢复期患者的临床疗效确切,可有效改善患者神经功能及预后,且安全性较高。

Objective To observe the influence of ginkgolide injection combined with clopidogrel on the neurologic function and prognosis of elderly cerebral infarction convalescence patients.Methods A total of 80 cases of elderly patients with cerebral infarction convalescence were selected from May 2015 to May 2017 in Ya＇ an People＇ s Hospital, which were divided into control group and observation group according to random number table method, 40 cases in each group.The control group was treated with clopidogrel alone, the observation group was treated with ginkgolide injection on the basis of control group, both groups were treated for 2 weeks.The NIHSS scores before and after treatment, prognosis and the incidence of adverse reactions were compared between the two groups.Results Before treatment, no significant difference of NIHSS scores was found between the two groups （ P〉0.05 ） ; after treatment, the NIHSS scores in observation group was lower than control group （ P〈0.05 ）. The observation group of prognosis was better than control group （ P〈0.05 ） .There was no siginificant difference of the incidence rate of adverse reactions between the two groups （ P〉0.05 ） .Conclusion Ginkgolide injection combined with clopidogrel have an exactly clinical effect in treating elderly cerebral infarction convalescence patients, it can effectively improve the neurologic function and prognosis of patients, and with high safety.