地西泮联合苯巴比妥钠治疗癫痫持续状态的临床疗效

Clinical efficacy of diazepam combined with phenobarbital sodium in the treatment of status epilepticus

目的探讨地西泮联合苯巴比妥钠治疗癫痫持续状态(SE)的临床疗效。方法选取长治医学院附属和济医院神经内科2016年3月—2017年8月收治的SE患者64例,随机分为对照组和试验组,每组32例。对照组患者给予苯巴比妥钠治疗,试验组患者在对照组基础上给予地西泮治疗。比较两组患者癫痫发作控制时间、插管时间、意识恢复时间、临床疗效,并观察患者治疗期间不良反应及并发症发生情况。结果试验组患者癫痫发作控制时间、插管时间及意识恢复时间均短于对照组(P<0.05)。试验组患者治疗总有效率高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05);试验组患者并发症发生率低于对照组(P<0.05)。结论采用地西泮联合苯巴比妥钠治疗SE的临床疗效确切,可快速促进患者意识恢复,且安全性高。

Objective To investigate the clinical efficacy of diazepam combined with phenobarbital sodium in the treatment of status epilepticus （ SE ） .Methods A total of 64 cases of SE patients were selected from March 2016 to August 2017 in Heji Hospital Affiliated to Changzhi Medical College, which were randomly divided into control group and experimental group, 32 cases in each group.The control group was given phenobarbital sodium, experimental group was given diazepam based on control group.The duration of seizure control, intubation time, consciousness recovery time, clinical effect were compared between the two groups, and the incidence of adverse reactions and complications were observed.Results The experimental group of duration of seizure control, intubation time, consciousness recovery time were shorter than control group （ P〈0.05 ） . The total effective rate in experimental group was higher than control group （ P〈0.05 ） .There was no significant difference of the incidence rate of adverse reactions between the two groups （ P〉0.05 ） ; the incidence rate of complications in experimental group was lower than control group （ P〈0.05 ） .Conclusion Diazepam combined with phenobarbital sodium have a significant clinical effect in treating patients with SE, which can quickly promote recovery of patients＇ consciousness, and with high safety.