维生素AD滴剂治疗小儿反复呼吸道感染的临床疗效

Clinical effect of vitamin AD drops in the treatment of infantile repeated respiratory infection

目的探讨维生素AD滴剂治疗小儿反复呼吸道感染的临床疗效。方法选择澧县妇幼保健计划生育服务中心儿童保健科2015年12月—2016年12月收治的反复呼吸道感染患儿96例,随机分为对照组与观察组,各49例。对照组采用匹多莫德颗粒治疗,观察组在对照组的基础上加用维生素AD滴剂治疗,两组患儿均持续治疗3个月。比较两组患儿临床疗效,治疗前后Ig G、Ig M、Ig A、T淋巴细胞亚群(CD3+CD4+细胞分数、CD3+CD8+细胞分数、CD4+/CD8+细胞比值)水平。结果观察组临床疗效优于对照组(P<0.05)。治疗前,两组患儿Ig G、Ig M、Ig A、CD3+CD4+细胞分数、CD3+CD8+细胞分数、CD4+/CD8+细胞比值比较,差异有统计学意义(P>0.05);治疗后,观察组患儿Ig G、Ig M、Ig A、CD3+CD4+细胞分数、CD3+CD8+细胞分数、CD4+/CD8+细胞比值高于对照组(P<0.05)。结论在匹多莫德治疗基础上加用维生素AD滴剂治疗小儿反复呼吸道感染的临床疗效较佳,可改善患儿的免疫功能。

Objective To discuss the clinical effect of vitamin AD drops in the treatment of infantile repeated respiratory infection.Methods A total of 96 cases of repeated respiratory infection children were selected from December 2015 to December 2016 in Lixian Maternal and Child Health Family Planning Service Center, which were randomly divided into control group and observation group, 49 cases in each group.The control group was given pidotimod granules, observation group was given vitamin AD drops based on control group, both groups were treated for 3 months.The clinical effect, IgG, IgM, IgA, T lymphocyte subsets （CD3^＋CD4^＋, CD3^＋CD8^＋, CD4^＋/CD8^＋ ） before and after treatment were compared between the two groups.Results The clinical effect of observation group was better than control group （P〈0.05） .Before treatment, no significant differences of IgG, IgM, IgA or CD3^＋CD4^＋, CD3^＋CD8^＋, CD4^＋/CD8^＋ was found between the two groups （ P〉0.05 ） ; after treatment, the observation group of IgG, IgM, IgA, CD3^＋CD4^＋, CD3^＋CD8^＋, CD4^＋/CD8^＋ were higher than control group （ P〈0.05 ） .Conclusion On the basis of pidotimod granules, vitamin AD drops have a better clinical effect in the treatment of infantile repeated respiratory infection, it can effectively improve the immune function of children.