垂体后叶素在腹腔镜保守手术治疗输卵管妊娠中的效果

Effect of Pituitrin in the treatment of tubal pregnancy by laparoscopy conservative operation

目的探讨垂体后叶素在腹腔镜保守手术治疗输卵管妊娠中的效果。方法选取我院2015年4月~2016年9月接诊的120例输卵管妊娠患者,采用随机数字表法分为观察组和对照组,每组各60例。对照组行腹腔镜保守手术治疗,观察组于腹腔镜保守手术前在输卵管系膜中注射垂体后叶素。比较两组治疗的临床效果,记录术后出血量、止血时间、手术时间、住院时间、术后体温,记录术前、术后1、4、7 d血β-HCG值变化,比较患者输卵管畅通率和持续异位妊娠发生率。结果治疗后,观察组的总有效率为98.33%,高于对照组(86.67%)(P<0.05);观察组术后出血量明显少于对照组,止血时间、手术时间以及住院时间均明显短于对照组(P<0.05);观察组术后体温(37.35±0.65)℃明显低于对照组的(37.62±0.48)℃(P<0.05)。术后4、7 d,观察组的人绒毛膜促性腺激素(β-HCG)水平均明显低于对照组(P<0.05);观察组输卵管畅通率为81.67%,明显高于对照组(51.67%)(P<0.05);观察组持续性异位妊娠发生率为0.00%,明显低于对照组(15.00%),差异均有统计学意义(P<0.05)。结论垂体后叶素在腹腔镜保守手术治疗输卵管妊娠中的效果良好,降低血β-HCG值,提高输卵管畅通率,持续性异位妊娠发生率,效果显著,值得推广。

Objective To investigate the effect of Pituitrin in the treatment of tubal pregnancy by laparoscopy conservative operation. Methods A total of 120 cases of oval tube pregnancy were selected from April 2015 to September 2016 in our hospital, all patients were divided into observation group and control group according to random number tablt method, 60 cases in each group. The control group was treated with laparoscopic conservative surgery, and the patients in the observation group were injected with Pituitrin in the fallopian tube mesangial membrane before laparoscopy. The clinical effect of the patients after treatment, volume, hemostasis time, operation time, hospitalization time, postoperative bleeding in patients with postoperative body temperature records, records of patients before and after 1 and 4 days after the operation, after 7 days of blood beta-HCG value change, pregnancy rate were recorded and compared with continuous flow rate of ectopic oviduct tube. Results After treatment, the total efficiency of observation group was 98.33%, higher than 86.67% in the control group（P〈0.05）; the postoperative bleeding of the observation group was significantly lesser than the control group, the bleeding time, operation time and hospitalization time were significantly shorter than the control group（P〈0.05）; the observation group postoperative body temperature（[37.35±0.65] ℃） was significantly lower than that of the control group（[37.62±0.48] ℃）（P〈0.05）. After 7 days, 4 days after operation, the level of β-HCG of the observation group were significantly lower than that of the control group（P〈0.05）; the tubal flow rate of the observation group was 81.67%,higher than the control group of 51.67%（P〈0.05）; the incidence of persistent ectopic pregnancy of the observation group was 0.00%, significantly lower than the control group of 15.00%, the differences were statistically significant（P〈0.05）. Conclusion Pituitrin is effective in laparoscopic conservative surgery for tubal pregnancy, and it can reduce blood beta-HCG value, improve tubal smooth rate and persistent ectopic pregnancy rate, and is worthy of promotion.