关注帕金森病患者的体重减轻

Focusing on weight loss in patients with Parkinson＇s disease

帕金森病的非运动症状对患者的生活质量影响巨大，近年来日渐受到重视。体重减轻也是帕金森病常见的非运动症状之一，与其他运动和非运动症状之间存在密切的相互作用。体重减轻贯穿帕金森病全程，可以作为预警症状先于运动症状出现；也可以作为危险因素引起营养不良、骨折、感染等并发症，还可以增加异动症风险。另一方面，加强体重相关的能量平衡调控则有望修饰神经变性进程。因此，体重减轻的监测与管理对帕金森病的发生发展具有重要意义。尽管体重减轻很早就被观察到，但长期以来未得到应有的重视。我们对帕金森病体重减轻的现象学及其机制作简要回顾，旨在提高对帕金森病体重变化的关注。

Nowadays more and more attention has been attracted to non-motor symptoms （NMS）, which are negatively associated with the life quality of patients with Parkinson＇s disease （PD）. Weight loss, one of commonly observed NMS, interacts with other motor and NMS, complicating the disease progression. Weight loss may occur during the whole course of PD, even several years before the onset of motor symptoms, ensuing clinical problems such as malnutrition, bone fracture and infection, and inducing an increased risk of dyskinesia. Increasing evidence demonstrated that metabolic manipulation may provide a promising disease-modifying therapeutic alternative in future management of PD. Accordingly, monitoring and managing weight loss in PD is of great importance in clinical practice. Although weight loss is commonly documented, it is neglected frequently up to now. Hence, we present current knowledge of weight loss in the context of PD, aiming to appeal clinicians and researchers to pay a closer attention to this phenomena and enable better management and therapeutic strategies in future clinical practice.