舍曲林联合阿立哌唑治疗精神分裂症合并抑郁症状的疗效观察

Observation on Efficacy of Sertraline Combined with Aripiprazole in Treatment of Schizophrenia Complicated with Depression

目的:探讨舍曲林联合阿立哌唑治疗精神分裂症合并抑郁症状的临床疗效。方法:选取2015年8月至2017年8月惠州市复员退伍军人医院和惠州市第二人民医院收治的精神分裂症合并抑郁症状患者88例作为研究对象,采用电脑软件随机均分为观察组和对照组,每组44例。对照组患者给予阿立哌唑口腔崩解片治疗,观察组患者在对照组的基础上加用舍曲林片治疗。对比两组患者的临床疗效、阳性和阴性症状量表评分、汉密尔顿抑郁量表评分及不良反应发生情况的差异。结果:观察组患者的总有效率为86.36%(38/44),明显高于对照组的68.18%(30/44),差异有统计学意义(P<0.05);治疗2、4及8周后,观察组患者的阳性和阴性症状量表评分、汉密尔顿抑郁量表评分明显低于对照组,差异均有统计学意义(P<0.05);观察组、对照组患者的不良反应发生率分别为11.36%(5/44)、15.91%(7/44),差异无统计学意义(P>0.05)。结论:舍曲林联合阿立哌唑治疗精神分裂症合并抑郁症状的疗效确切,能够同时改善精神分裂和抑郁症状,且安全性较高。

OBJECTIVE： To probe into the clinical efficacy of sertraline combined with aripiprazole in treatment of schizophrenia complicated with depression. METHODS： 88 cases with schizophrenia complicated with depression admitted into Demobilized Veterans Hospital and the Second People＇s Hospital of Huizhou from Aug. 2015 to Aug.2017 were extracted to be divided into observation group and control group via the computer software,with 44 cases in each. The control group was given Aripiprazole orally disintegrating tablets,while the observation group additionally received sertraline based on the control group. The clinical efficacy,positive and negative symptom scores,Hamilton depression rating scale and incidence of adverse drug reactions of two groups were compared. RESULTS： The total effective rate of observation group was 86. 36%（ 38/44）,significantly higher than that of control group [68. 18%（ 30/44） ],with statistically significant difference（ P〈0. 05）. After treatment of 2,4 and 8 weeks,the positive and negative symptom scores and Hamilton depression rating scale of observation group were significantly lower than those of control group,with statistically significant differences（ P〈0. 05）. The incidences of adverse drug reactions of two groups were respectively 11. 36%（ 5/44） and 15. 91%（ 7/44）,without any statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy sertraline combined with aripiprazole in treatment of schizophrenia complicated with depression is significant,which can effectively improve the schizophrenia and depression,with higher safety.