二甲双胍联合门冬胰岛素注射液30治疗儿童1型糖尿病的疗效观察

Observation on Efficacy Metformin Combined with Insulin Aspart 30 Injection in Treatment of Type Ⅰ Diabetes Mellitus in Children

目的:探讨二甲双胍联合门冬胰岛素注射液30治疗儿童1型糖尿病(TypeⅠdiabetes mellitus,T1DM)的临床疗效。方法:选取2007年8月至2017年12月怒江州人民医院收治的10岁以上T1DM患儿70例,采用随机数字表法分为观察组(34例)和对照组(36例)。对照组患儿采用门冬胰岛素注射液30治疗,观察组患儿在对照组治疗措施上加用二甲双胍。比较两组患儿治疗前后空腹血糖(FBG)、餐后2 h血糖(2 hBG)水平,血糖达标时间、胰岛素日用量、低血糖发生次数、住院时间和治疗前后血生化指标水平。结果:治疗后,两组患儿的FBG、2 hBG水平较治疗前明显改善,差异均有统计学意义(P<0.05),但两组间的差异无统计学意义(P>0.05);观察组患儿血糖达标时间、胰岛素日用量、低血糖发生次数及住院时间均明显优于对照组,差异均有统计学意义(P<0.05);两组患儿治疗前后ALT、AST、TBIL、ALB、La、SCr及BUN水平的差异均无统计学意义(P>0.05)。结论:二甲双胍联合门冬胰岛素注射液30治疗儿童T1DM的临床疗效显著,且安全性较高。

OBJECTIVE： To probe into the clinical efficacy of metformin combined with insulin aspart 30 injection in treatment of type Ⅰ diabetes mellitus（ T1 DM） in children. METHODS： 70 child patients aged over 10 with T1DM admitted into People＇s Hospital of Nujiang Prefecture from Aug. 2007 to Dec. 2017 were selected and divided into observation group（ 34 cases） and control group（ 36 cases） via random number table. The control group was treated with insulin aspart 30 injection,while the observation group was given metformin combined with insulin aspart 30 injection. Differences in fasting blood glucose（ FBG） and 2 h postprandial blood glucose（ 2 hBG） levels,times for blood glucose control,daily dosages of insulin,frequencies of hypoglycemia,hospital stays,blood biochemical indices before and after treatment between two groups were compared. RESULTS： After treatment,the FBG and 2 hBG levels of both groups had been significantly improved,with statistically significant differences（ P〈0. 05）,while no statistical significance in differences between two groups（ P〉0. 05）; the times for blood glucose control,daily dosages of insulin,frequencies of hypoglycemia and hospital stays of observation group were significantly better than those of the control group,with statistically significant differences（ P〈0. 05）; there was no statistical significance in differences of ALT,AST,TBIL,ALB,La,Scr and BUN levels between two groups before and after treatment（ P〉0. 05）. CONCLUSIONS： The efficacy of metformin combined with insulin aspart 30 injection in treatment of T1DM is remarkable,with high safety.