盐酸坦索罗辛联合丁胺卡那霉素治疗慢性前列腺炎的疗效观察

Observation on Efficacy of Tamsulosin Hydrochloride Combined with Amikacin in Treatment of Chronic Prostatitis

目的:盐酸坦索罗辛联合丁胺卡那霉素治疗慢性前列腺炎的疗效观察及对患者白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平的影响。方法:选取2014—2017年在湖北省谷城县人民医院进行治疗的慢性前列腺炎患者110例,按照随机数字表法分为对照组和观察组,每组55例。对照组患者给予丁胺卡那霉素治疗,观察组患者在对照组治疗基础上加用盐酸坦索罗辛,比较两组患者的临床疗效、临床指标评分、最大尿流率、尿道压力改变情况及IL-8、TNF-α水平。结果:观察组患者的总有效率为89.09%(49/55),明显高于对照组的74.55%(41/55),差异有统计学意义(P<0.05)。治疗后,两组患者疼痛症状评分、生活质量评分的差异无统计学意义(P>0.05),但观察组患者的排尿症状评分明显低于对照组,差异有统计学意义(P<0.05);观察组患者的最大尿流率明显大于对照组,最大尿道闭合压、最大尿道压明显小于对照组,差异均有统计学意义(P<0.05);观察组患者的IL-8、TNF-α水平明显低于对照组,差异均有统计学意义(P<0.05)。结论:盐酸坦索罗辛联合丁胺卡那霉素能有效提高慢性前列腺炎的临床治疗效果,可缓解患者尿道压力从而改善排尿情况,并可减轻炎症反应。

OBJECTIVE： To probe into the efficacy of tamsulosin hydrochloride combined with amikacin in treatment of chronic prostatitis and its effects on patients interleukin-8（ IL-8） and tumor neurosis factor-α（ TNF-α）levels. METHODS： 110 patients with chronic prostatitis admitted into Hubei Gucheng County People＇s Hospital from2014 to 2016 were selected and divided into control group and observation group via random number table,with 55 cases in each group. The control group was treated with amikacin,while the observation group was given tamsulosin hydrochloride combined with amikacin,Differences in clinical efficacy,scores of clinical indices,maximum flow rate,changes of urethral pressure,IL-8 and TNF-α levels between two groups were compared. RESULTS： The total effective rate of observation group was 89. 09%（ 49/55）,which was significantly higher than that of the control group（ 74. 55%,41/55）,with statistically significant difference（ P〈0. 05）. After treatment,there was no statistical significance in differences in scores of pain evaluation and life quality between two groups（ P〉0. 05）,while the score of CPSI-U of observation group was significantly lower than that of the control group,with statistically significant difference（ P〈0. 05）; the maximum flow rate of observation group was significantly higher than that of the control group,with significantly lower maximum urethral closure pressure and maximum urethral pressure,with statistically significant differences（ P〈0. 05）; the IL-8 and TNF-α levels of observation group were significantly lower than those of the control group,with statistically significant differences（ P〈0. 05）. CONCLUSIONS： Tamsulosin hydrochloride combined with amikacin can effectively improve the efficacy in treatment of chronic prostatitis,which can relieve urethral pressure,improve urinating condition and alleviate inflammatory reaction.