麻醉药对神经干(祖)细胞生物学效应影响的研究进展

Research Progress in Biological Effect of Anesthetic on Neural Stem (Progenitor) Cell

麻醉药对患者尤其是处在大脑快速发育期的青少年患者的影响是关注的焦点。目前,麻醉药对神经干细胞生物学行为影响的研究主要集中在神经干细胞的自我更新、增殖、分化、凋亡等方面。一些麻醉药对神经干细胞的影响具有浓度-时间效应,通过一些经典的途径如Wnt、Caspase、Sox2等来影响,调控这些通路的MicroRNA而发挥作用。未来的研究一方面是从体内和体外两方面深入探究造成这些影响的机制,另一方面是利用神经干细胞对麻醉药的特性进行高通量评价。

The impact of anesthetics on patients,especially in young people with rapid brain development,is the focus of attention. Currently,researches are focused on the self-renew,proliferation,differentiation and apoptosis of the neural stem（ progenitor） cell. The impaction of some anesthetics is concentration-dependent and duration-dependent via some classics signal pathways,e.g. Wnt,Caspase,Sox2,as well as the MicroRNA which is in the upper of these pathways. The future research will concentrate on the mechanisms of these effects in vivo and in vitro as well as the high throughput evaluation by using the characteristics of anesthetics on neural stem（ progenitor） cell.