血清降钙素原、C-反应蛋白在新生儿感染的临床应用

Clinical Application of Serum Procalcitonin and C Reactive Protein in the Infection of Newborns

目的探究C-反应蛋白和血清降钙素原检测在新生儿感染中的临床诊断价值。方法方便择取2016年5月—2017年11月期间收治的30例新生儿感染患者,设其为研究组;择取同期进行生化检验的30名健康新生儿,设其为对照组。为两组研究对象进行C-反应蛋白和血清降钙素原的检测,并对比两组研究对象的诊断结果。为研究组患儿采取治疗,对比其治疗前后的C-反应蛋白和血清降钙素原水平。结果对照组的血清降钙素原水平为(0.16±0.09)ng/mL,C-反应蛋白水平为(5.73±1.71)mg/L,研究组的血清降钙素原水平为(4.47±1.33)ng/mL,C-反应蛋白水平为(28.37±13.34)mg/L,两组差异有统计学意义(t=17.709、9.220,P=0.000<0.05)。研究组治疗后的血清降钙素原水平为(1.99±0.32)ng/mL,C-反应蛋白水平为(7.99±2.13)mg/L,与治疗前相比,差异有统计学意义(t=9.930、8.263,P=0.000<0.05)。结论通过C-反应蛋白和血清降钙素原检测可以清晰辨别新生儿是否发生感染,同时还可以借助这两项指标来判断患儿的治疗效果。

Objective To study the value of serum procalcitonin and C reactive protein in the infection of newborns. Methods 30 cases of newborns with infection admitted and treated in our hospital from May 2016 to November 2017 were convenient selected as the research group, while 30 cases of healthy physical examination newborns for biochemical test at the same period were selected as the control group, and the C reactive protein and serum procalcitonin were tested, and the diagnosis results of the two groups was compared, and the serum procalcitonin and C reactive protein were compared before and after treatment. Results The serum procalcitonin level and C reactive protein level in the research group and in the control group were respectively（0.16±0.09）ng/mL,（5.73±1.71）mg/L and（4.47±1.33）ng/mL,（28.37±13.34）mg/L, and the differences were statistically significant（t=17.709、9.220,P=0.0000.05）, and the serum procalcitonin level and C reactive protein level in the research group after treatment were respectively（1.99±0.32）ng/mL and（7.99±2.13）mg/L, and the differences before and after treatment were statistically significant（t=9.930、8.263,P=0.0000.05）. Conclusion The serum procalcitonin and C reactive protein can clearly distinguish whether the newborns are infectious or not, and we can use the two indicators to determine the treatment effect of newborns.