甲基强的松龙联合丙种球蛋白治疗腹型过敏性紫癜患儿的效果分析

Analysis of Effect of Methylprednisolone Combined with Gamma Globulin in Treatment of Children with Abdominal Allergic Purpura

目的研究探讨甲基强的松龙联合丙种球蛋白治疗腹型过敏性紫癜患儿的效果。方法方便选择2015年1月—2017年1月该院过敏性紫癜患儿68例进行研究讨论,把所有患者随机分为两组,两组都为34例,其中对照组采用甲基强的松龙治疗,观察组采取甲基强的松龙联合丙种球蛋白治疗,观察两组患者的治疗效果。结果观察组患者皮疹消失时间、血便消失、住院时间、疼痛缓解时间分别为(20.5±10.5)、(4.01±1.35)、(4.0±1.3)、(3.1±1.5)d,均短于对照组,两组差异有统计学意义(t=6.118、4.179、4.312、4.008,P<0.05)。观察组紫癜复发率、并发症发生率分别为5.88%、8.82%,均小于对照组,两组差异有统计学意义(χ~2=4.101、3.112,P<0.05)。结论对于腹型过敏性紫癜的患者,采取甲基强的松龙联合丙种球蛋白治疗,疗效显著,可以减少患者的复发次数,减少患者的住院时间,从而减轻患者的压力,值得应用。

Objective To study the effect of methylprednisolone combined with gamma globulin in treatment of children with abdominal allergic purpura. Methods 68 cases of children with abdominal allergic purpura admitted and treated in our hospital from January 2015 to January 2017 were conveniently selected and randomly divided into two groups with 34 cases in each, the control group were treated with methylprednisolone, while the observation group were treated with methylprednisolone combined with gamma globulin, and the treatment effect was compared between the two groups. Results The rash disappearance time, bloody stool disappearance, length of stay and pains relief time in the observation group were respectively（20.5±10.5）d,（4.01±1.35）d,（4.0±1.3）d,（3.1 ±1.5）d, which were shorter than those in the control group, and the differences between groups were statistically significant（t=6.118,4.179,4.312,4.008,P〈0.05）, and the recurrence rate of pelioma and incidence rate of complications in the observation group were respectively 5.88%,8.82%, which were lower than those in the control group, and the differences were statistically significant（χ~2=4.101,3.112,P〈0.05）. Conclusion The curative effect of methylprednisolone combined with gamma globulin in treatment of children with abdominal allergic purpura is obvious, which can reduce the recurrence frequency of patients and length of stay thus relieving the pressure, which is worth application.