慢性HBV感染者抗-HBc定量检测的临床意义

Clinical value of anti-HBc quantification for chronic HBV infection

作为国家十二五重大专项课题的成果,抗-HBc定量检测技术已经获得上市批准,有望在临床推广应用。我国学者对抗-HBc的临床意义进行了多方面研究探索,研究结果显示了其在慢性HBV感染自然史、基线抗病毒治疗预测等方面具有较好的应用价值。研究发现抗-HBc与ALT呈明显正相关,与肝脏炎症明显相关,尤其在ALT正常慢性HBV感染者中,抗-HBc可以弥补ALT的不足,对此类患者临床治疗决策的制订具有重要意义。

As the achivement of a major project during the 12th Five-year Plan Period in China,the technique of anti-HBc quantification has been approved for commercial use and holds promise for wide application in clinical practice.Chinese scholars have explored the clinical significance of anti-HBc in various aspects and found that it has great values in the assessment of natural course of chronic hepatitis B virus （HBV） infection and the baseline prediction of antiviral therapy.Studies have shown that anti-HBc is significantly positively correlated with alanine aminotransferase （ALT） and significantly associated with liver inflammation.In chronic HBV infection patients with a normal ALT level,anti-HBc can be used instead as an indicator,with great significance for the development of therapeutic strategy in such patients.